The overall objective of this project is to develop techniques and ultimately a system which will allow the rapid, objective and quantitative analysis of brain scan data obtained from computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). This entails relating the scans to a computer based atlas of the human brain for objective determination of anatomic information with which to relate the functional image. We plan to develop a system with """"""""user friendly software"""""""" (e.g. simple to use by clinicians and basic researchers). We expect that the system will be highly interactive and will provide real-time analytic feedback abilities to the user. Techniques will be developed for the interactive display, manipulation, and image processing of 3-D data. A 3-D Voxel representation of a standard Atlas of the human brain as well as of clinical CT, MRI or PET data will be implemented. Image processing capabilities will include automatic thresholding, reslicing in any arbitrary plane, calculation of various statistics, and highlighting outlines or areas of interest. The display capabilities will include real-time translation, rotation, scaling, segmentation, and enhancement of 3-D medical objects. Interactive editing of such 3-D medical objects and the merging of multiple modalities (i.e., CT and MRI) for comparison and analysis will also be supported.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS023636-03
Application #
3407379
Study Section
(SSS)
Project Start
1986-08-01
Project End
1989-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Dann, R; Hoford, J; Kovacic, S et al. (1989) Evaluation of elastic matching system for anatomic (CT, MR) and functional (PET) cerebral images. J Comput Assist Tomogr 13:603-11
Goldwasser, S M; Reynolds, R A; Talton, D A et al. (1988) Techniques for the rapid display and manipulation of 3-D biomedical data. Comput Med Imaging Graph 12:1-24