Structure and Function of A2 - Adrenergic Receptor

Sharma, Rameshwar K.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS023744-02
• Application #: 3407570
• Study Section: Physiological Chemistry Study Section (PC)
• Project Start: 1986-12-01
• Project End: 1988-04-30
• Budget Start: 1988-01-01
• Budget End: 1988-04-30
• Support Year: 2
• Fiscal Year: 1988

Institution

• Name: University of Tennessee Health Science Center
• Type: Schools of Medicine
• DUNS #: 941884009
• City: Memphis
• State: TN
• Country: United States
• Zip Code: 38163

Publications

Venkataraman, V; Duda, T; Sharma, R K (1999) alpha2D/A-adrenergic receptor gene induction in the retina by phorbol ester: involvement of an AP-2 element. Genes Cells 4:161-73

Duda, T; Venkataraman, V; Goraczniak, R et al. (1999) Functional consequences of a rod outer segment membrane guanylate cyclase (ROS-GC1) gene mutation linked with Leber's congenital amaurosis. Biochemistry 38:509-15

Duda, T; Venkataraman, V; Krishnan, A et al. (1998) Rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) gene: structure, organization and regulation by phorbol ester, a protein kinase C activator. Mol Cell Biochem 189:63-70

Duda, T; Goraczniak, R M; Pozdnyakov, N et al. (1998) Differential activation of rod outer segment membrane guanylate cyclases, ROS-GC1 and ROS-GC2, by CD-GCAP and identification of the signaling domain. Biochem Biophys Res Commun 242:118-22

Krishnan, A; Goraczniak, R M; Duda, T et al. (1998) Third calcium-modulated rod outer segment membrane guanylate cyclase transduction mechanism. Mol Cell Biochem 178:251-9

Venkataraman, V; Duda, T; Sharma, R K (1998) The alpha(2D/A)-adrenergic receptor-linked membrane guanylate cyclase: a new signal transduction system in the pineal gland. FEBS Lett 427:69-73

Sharma, R K; Duda, T (1997) Plasma membrane guanylate cyclase. A multimodule transduction system. Adv Exp Med Biol 407:271-9

Venkataraman, V; Duda, T; Sharma, R K (1997) A role for amino acid residues in the third cytoplasmic loop in defining the ligand binding characteristics of the alpha2D-adrenergic receptor. Mol Cell Biochem 177:125-9

Venkataraman, V; Duda, T; Sharma, R K (1997) The bovine alpha 2D-adrenergic receptor gene: structure, expression in retina, and pharmacological characterization of the encoded receptor. Mol Cell Biochem 177:113-23

Goraczniak, R; Duda, T; Sharma, R K (1997) Structural and functional characterization of a second subfamily member of the calcium-modulated bovine rod outer segment membrane guanylate cyclase, ROS-GC2. Biochem Biophys Res Commun 234:666-70