Abstract

The human immunodeficiency virus HIV (formerly called HTLV- III/LAV) has now been clearly shown to be the etiologic agent of the acquired immunodeficiency syndrome (AIDS). HIV has also been implicated in the etiology of the progressive encephalopathy which occurs in children with AIDS. HIV is related to retroviruses of the lentivirus subfamily, which may remain inactive (latent) for long periods, or become active with cytopathic effect in target tissues, thus posing a severe problem for therapy in cases of central nervous system (CNS) involvement. We propose to assay HIV antigen expression in the cerebrospinal fluid (CSF) of children with HIV infection as a marker of viral activity, and to correlate this assay with clinical neurologic status as an index of disease progression. Importantly, the existence of a large number of intravenous drug abusing (IVDA) AIDS families among our patient population will allow us to perform longitudinal studies in a significant number of HIV-infected children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS025032-01
Application #
3410109
Study Section
(SSS)
Project Start
1987-07-01
Project End
1989-12-31
Budget Start
1987-07-01
Budget End
1988-12-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107

  Publications

Boucher, C A; de Jager, M H; Debouck, C et al. (1989) Antibody response to human immunodeficiency virus type 1 protease according to risk group and disease stage. J Clin Microbiol 27:1577-81
Portegies, P; Epstein, L G; Hung, S T et al. (1989) Human immunodeficiency virus type 1 antigen in cerebrospinal fluid. Correlation with clinical neurologic status. Arch Neurol 46:261-4
Mintz, M; Rapaport, R; Oleske, J M et al. (1989) Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency syndrome. Am J Dis Child 143:771-4
Epstein, L G (1989) Lentiviral encephalitides in the immature host: a comparison of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) brain infection. Brain Dev 11:353-9
Epstein, L G; Sharer, L R; Goudsmit, J (1988) Neurological and neuropathological features of human immunodeficiency virus infection in children. Ann Neurol 23 Suppl:S19-23
Esptein, L G; DiCarlo Jr, F J; Joshi, V V et al. (1988) Primary lymphoma of the central nervous system in children with acquired immunodeficiency syndrome. Pediatrics 82:355-63
Krone, W J; Debouck, C; Epstein, L G et al. (1988) Natural antibodies to HIV-tat epitopes and expression of HIV-1 genes in vivo. J Med Virol 26:261-70
Goudsmit, J; Boucher, C A; Meloen, R H et al. (1988) Human antibody response to a strain-specific HIV-1 gp120 epitope associated with cell fusion inhibition. AIDS 2:157-64
Michaels, J; Sharer, L R; Epstein, L G (1988) Human immunodeficiency virus type 1 (HIV-1) infection of the nervous system: a review. Immunodefic Rev 1:71-104
Sharer, L R; Baskin, G B; Cho, E S et al. (1988) Comparison of simian immunodeficiency virus and human immunodeficiency virus encephalitides in the immature host. Ann Neurol 23 Suppl:S108-12

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