Abstract

We propose to map genes which cause the autosomal dominant neurological diseases episodic ataxia, familial periodic paralysis and paroxysmal dystonic choreoathetosis. These diseases are characterized by episodes of neurologic dysfunction interspersed with symptom-free intervals. For each of these diseases, we have access to families with multiple affected members totalling approximately 250 for all families. Informative families will be typed with cloned DNA probes derived from candidate genes and from arbitrary genomic regions that reveal restriction fragment length polymorphisms (RFLP) with polymorphism information contents (PIC) that generally exceed 0.5. Our proposed studies will contribute to the localization of one or more neurological disease genes and may also indicate to what extent genetic heterogeneity exists within these disease classes. These studies constitute the first step towards the ultimate goal of cloning the genes responsible for the disorders and characterizing the structures and functions of the abnormal gene products and their normal homologs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS025370-03
Application #
3410641
Study Section
Neurology C Study Section (NEUC)
Project Start
1988-02-01
Project End
1992-01-31
Budget Start
1990-02-01
Budget End
1992-01-31
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Larson, Susan J; Romanoff, Rachelle L; Dunn, Adrian J et al. (2002) Effects of interleukin-1beta on food-maintained behavior in the mouse. Brain Behav Immun 16:398-410
Swiergiel, Artur H; Dunn, Adrian J (2002) Distinct roles for cyclooxygenases 1 and 2 in interleukin-1-induced behavioral changes. J Pharmacol Exp Ther 302:1031-6
Dunn, A J; Swiergiel, A H (2000) The role of cyclooxygenases in endotoxin- and interleukin-1-induced hypophagia. Brain Behav Immun 14:141-52
Dunn, A J (2000) Effects of the IL-1 receptor antagonist on the IL-1- and endotoxin-induced activation of the HPA axis and cerebral biogenic amines in mice. Neuroimmunomodulation 7:36-45
Ando, T; Brown, R F; Berg, R D et al. (2000) Bacterial translocation can increase plasma corticosterone and brain catecholamine and indoleamine metabolism. Am J Physiol Regul Integr Comp Physiol 279:R2164-72
Dunn, A J (2000) Cytokine activation of the HPA axis. Ann N Y Acad Sci 917:608-17
Swiergiel, A H; Dunn, A J (2000) Lack of evidence for a role of serotonin in interleukin-1-induced hypophagia. Pharmacol Biochem Behav 65:531-7
Barkhudaryan, N; Dunn, A J (1999) Molecular mechanisms of actions of interleukin-6 on the brain, with special reference to serotonin and the hypothalamo-pituitary-adrenocortical axis. Neurochem Res 24:1169-80
Dunn, A J; Wang, J; Ando, T (1999) Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress. Adv Exp Med Biol 461:117-27
Swiergiel, A H; Dunn, A J (1999) CRF-deficient mice respond like wild-type mice to hypophagic stimuli. Pharmacol Biochem Behav 64:59-64

Showing the most recent 10 out of 24 publications