Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS025879-08
Application #
2265709
Study Section
Virology Study Section (VR)
Project Start
1988-04-01
Project End
1998-04-30
Budget Start
1996-07-01
Budget End
1997-04-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Genetics
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Sawtell, N M (1998) The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia. J Virol 72:6888-92
Sawtell, N M; Poon, D K; Tansky, C S et al. (1998) The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation. J Virol 72:5343-50
Sawtell, N M (1997) Comprehensive quantification of herpes simplex virus latency at the single-cell level. J Virol 71:5423-31
Thompson, R L; Sawtell, N M (1997) The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. J Virol 71:5432-40
Pyles, R B; Thompson, R L (1994) Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells. J Virol 68:4514-24
Pyles, R B; Thompson, R L (1994) Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system. J Virol 68:4963-72
Bolovan, C A; Sawtell, N M; Thompson, R L (1994) ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. J Virol 68:48-55
Sawtell, N M; Thompson, R L (1992) Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. J Virol 66:2150-6
Pyles, R B; Sawtell, N M; Thompson, R L (1992) Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency. J Virol 66:6706-13
Sawtell, N M; Thompson, R L (1992) Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. J Virol 66:2157-69

Showing the most recent 10 out of 11 publications