Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS025986-04
Application #
3411575
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1989-08-01
Project End
1992-12-31
Budget Start
1992-03-20
Budget End
1992-12-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
McCauley, L D; Park, C H; Lan, N C et al. (1995) Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria. Eur J Pharmacol 276:145-53
McCauley, L D; Liu, V; Chen, J S et al. (1995) Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain. Mol Pharmacol 47:354-62
Lan, N C; Chen, J S; Johnson, D et al. (1995) Differential effects of 4'-chlorodiazepam on expressed human GABAA receptors. J Neurochem 64:684-8
Finn, D A; Gee, K W (1994) The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J Pharmacol Exp Ther 271:164-70
Finn, D A; Gee, K W (1993) A comparison of Ro 16-6028 with benzodiazepine receptor 'full agonists' on GABAA receptor function. Eur J Pharmacol 247:233-7
Finn, D A; Gee, K W (1993) The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex. J Pharmacol Exp Ther 265:1374-9
McCauley, L D; Lan, N C; Tomich, J M et al. (1992) Peripheral-type benzodiazepine receptors and the regulation of steroidogenesis in rat brain mitochondria. Adv Biochem Psychopharmacol 47:143-7
Cadoni, C; Gee, K W (1992) Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex. Eur J Pharmacol 227:147-51
Gee, K W; Lan, N C (1991) Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation. Mol Pharmacol 40:995-9
Lan, N C; Gee, K W; Bolger, M B et al. (1991) Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids. J Neurochem 57:1818-21

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