The broad goal of this work is to examine relationships between sleep and infectious disease. Subjective feelings of sleepiness often accompany infectious disease, and our preliminary results show that sleep patterns are altered in animals with bacterial and fungal infections. The basic hypotheses that sleep patterns are altered in animals with infectious disease and that sleep may promote resistance to disease or aid in the recuperative process will be investigated in this proposal. These issues are of considerable practical importance since: a) sleep may be an important sign of infectious disease, like fever and acute phase responses; b) altered vigilance during disease could seriously and adversely affect a large number of activities (eg., automobile operation); and c) although many individuals undergo periodic sleep deprivation (eg., students, shift workers), the impact of this deprivation upon health and immunity is uncertain. We will evaluate these hypotheses by examining: 1) the effects of bacterial and fungal infections on rabbit sleep, as well as the effects of appropriate therapeutic intervention and the influence of prior immune enhancement or impairment, and 2) the effects of sleep deprivation on immune function and susceptibility to infectious disease. Sleep will be evaluated by monitoring EEG, EEG slow-wave amplitude, and brain temperature. Assays evaluating immune function will include differential white cell counts, plasma cortisol levels, macrophage superoxide production, mitogenic responses of lymphocytes, and splenic antibody production. The proposed experiments will provide insights into both the influence of infectious disease on sleep and the influence of sleep on immune competence, susceptibility to infectious disease, and recuperative processes. Further, they may experimentally identify an adaptive function for sleep.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS026429-01A1
Application #
3412265
Study Section
Biopsychology Study Section (BPO)
Project Start
1989-04-01
Project End
1994-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Type
Graduate Schools
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
Trammell, Rita A; Brooks, Marjory; Cox, Lisa et al. (2006) Fatal hemorrhagic diathesis associated with mild factor IX deficiency in pl/J mice. Comp Med 56:426-34
Toth, Linda A; Hughes, Larry F (2006) Sleep and temperature responses of inbred mice with Candida albicans-induced pyelonephritis. Comp Med 56:252-61
Toth, Linda A; Hughes, Larry F (2004) Macrophage participation in influenza-induced sleep enhancement in C57BL/6J mice. Brain Behav Immun 18:375-89
Toth, L A; Verhulst, S J (2003) Strain differences in sleep patterns of healthy and influenza-infected inbred mice. Behav Genet 33:325-36
Toth, L A (2001) Identifying genetic influences on sleep: an approach to discovering the mechanisms of sleep regulation. Behav Genet 31:39-46
Toth, L A; Opp, M R (2001) Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice. Am J Physiol Regul Integr Comp Physiol 280:R1806-14
Hayes, K E; Raucci Jr, J A; Gades, N M et al. (2000) An evaluation of analgesic regimens for abdominal surgery in mice. Contemp Top Lab Anim Sci 39:18-23
Toth, L A (2000) Defining the moribund condition as an experimental endpoint for animal research. ILAR J 41:72-9
Taylor, R; Hayes, K E; Toth, L A (2000) Evaluation of an anesthetic regimen for retroorbital blood collection from mice. Contemp Top Lab Anim Sci 39:14-7
Xi, X; Toth, L A (2000) Lipopolysaccharide effects on neuronal activity in rat basal forebrain and hypothalamus during sleep and waking. Am J Physiol Regul Integr Comp Physiol 278:R620-7

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