Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS026662-07
Application #
2266041
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Oliver, Eugene J
Project Start
1988-12-01
Project End
1997-11-30
Budget Start
1995-12-15
Budget End
1997-11-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of South Alabama
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Ayling, J E; Bailey, S W; Boerth, S R et al. (2000) Hyperphenylalaninemia and 7-pterin excretion associated with mutations in 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH: analysis of enzyme activity in intestinal biopsies. Mol Genet Metab 70:179-88
Rebrin, I; Thony, B; Bailey, S W et al. (1998) Stereospecificity and catalytic function of histidine residues in 4a-hydroxy-tetrahydropterin dehydratase/DCoH. Biochemistry 37:11246-54
Bailey, S W; Ayling, J E (1997) Total chemical synthesis of chirally pure (6S)-tetrahydrofolic acid. Methods Enzymol 281:3-16
Rebrin, I; Bailey, S W; Boerth, S R et al. (1995) Catalytic characterization of 4a-hydroxytetrahydropterin dehydratase. Biochemistry 34:5801-10
Rebrin, I; Bailey, S W; Ayling, J E (1995) Activity of the bifunctional protein 4a-hydroxy-tetrahydropterin dehydratase/DCoH during human fetal development: correlation with dihydropteridine reductase activity and tetrahydrobiopterin levels. Biochem Biophys Res Commun 217:958-65
Bailey, S W; Boerth, S R; Dillard, S B et al. (1993) The mechanism of cofactor regeneration during phenylalanine hydroxylation. Adv Exp Med Biol 338:47-54
Waymire, J C; Ayling, J E; Craviso, G L (1993) Nicotinic cholinergic regulation of tetrahydrobiopterin levels in bovine adrenal chromaffin cells. Adv Exp Med Biol 338:235-8
Bailey, S W; Dillard, S B; Ayling, J E (1991) Role of C6 chirality of tetrahydropterin cofactor in catalysis and regulation of tyrosine and phenylalanine hydroxylases. Biochemistry 30:10226-35