Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS026818-06
Application #
2266129
Study Section
Neurology A Study Section (NEUA)
Project Start
1988-12-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Surgery
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Tomasevic, Gregor; Raghupathi, Ramesh; Scherbel, Uwe et al. (2010) Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice. J Neurosci Res 88:3414-23
Raghupathi, Ramesh; Muir, Judith K; Fulp, Carl T et al. (2003) Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death. Exp Neurol 183:438-48
Raghupathi, Ramesh; Strauss, Kenneth I; Zhang, Chen et al. (2003) Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat. J Neurotrauma 20:421-35
Williams, S; Raghupathi, R; MacKinnon, M A et al. (2001) In situ DNA fragmentation occurs in white matter up to 12 months after head injury in man. Acta Neuropathol (Berl) 102:581-90
Shaw, K; MacKinnon, M A; Raghupathi, R et al. (2001) TUNEL-positive staining in white and grey matter after fatal head injury in man. Clin Neuropathol 20:106-12
LaPlaca, M C; Zhang, J; Raghupathi, R et al. (2001) Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats. J Neurotrauma 18:369-76
Saatman, K E; Bareyre, F M; Grady, M S et al. (2001) Acute cytoskeletal alterations and cell death induced by experimental brain injury are attenuated by magnesium treatment and exacerbated by magnesium deficiency. J Neuropathol Exp Neurol 60:183-94
Laurer, H L; McIntosh, T K (2001) Pharmacologic therapy in traumatic brain injury: update on experimental treatment strategies. Curr Pharm Des 7:1505-16
Saatman, K E; Zhang, C; Bartus, R T et al. (2000) Behavioral efficacy of posttraumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis. J Cereb Blood Flow Metab 20:66-73
Graham, D I; Raghupathi, R; Saatman, K E et al. (2000) Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: relevance to human brain injury. Acta Neuropathol (Berl) 99:117-24

Showing the most recent 10 out of 60 publications