Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS026912-08
Application #
2266196
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1988-12-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Phillis, John W; O'Regan, Michael H (2003) Studies on taurine efflux from the rat cerebral cortex during exposure to hyposmotic, high K+ and ouabain-containing aCSF. Adv Exp Med Biol 526:433-44
Phillis, John W; O'Regan, Michael H (2002) Energy utilization in the ischemic/reperfused brain. Int Rev Neurobiol 51:377-414
Phillis, J W; Ren, J; O'Regan, M H (2001) Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex. J Neurochem 76:247-57
Guyot, L L; Diaz, F G; O'Regan, M H et al. (2001) Real-time measurement of glutamate release from the ischemic penumbra of the rat cerebral cortex using a focal middle cerebral artery occlusion model. Neurosci Lett 299:37-40
Guyot, L L; Diaz, F G; O'Regan, M H et al. (2001) The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex. Neurosurgery 48:385-90; discussion 390-1
Guyot, L L; Diaz, F G; O'Regan, M H et al. (2000) Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortex. Horm Metab Res 32:9-Jun
Phillis, J W; Ren, J; O'Regan, M H (2000) Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate. Brain Res 868:105-12
Guyot, L L; Diaz, F G; O'Regan, M H et al. (2000) Topical insulin and accumulation of excitotoxic and other amino acids in ischemic rat cerebral cortex. Proc Soc Exp Biol Med 224:28-31
Guyot, L L; Diaz, F G; O'Regan, M H et al. (2000) The effect of intravenous insulin on accumulation of excitotoxic and other amino acids in the ischemic rat cerebral cortex. Neurosci Lett 288:61-5
Phillis, J W; Ren, J; O'Regan, M H (2000) Inhibition of Na(+)/H(+) exchange by 5-(N-ethyl-N-isopropyl)-amiloride reduces free fatty acid efflux from the ischemic reperfused rat cerebral cortex. Brain Res 884:155-62

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