Abstract

This is an application to investigate the role of NO on the function of mesopontine cholinergic (MPCh) neurons. These neurons project to the thalamus and the basal forebrain and they have been implicated by a number of studies in sleep and attentional states. Considerable evidence suggests that these cells produce NO which functions in some way to regulate their own excitability. The idea is that since NO is a diffusible neuromoduulator it could play a role in coordinating the synchronous activity of a population of neurons thought to play a key role in behavioral state.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS027881-06
Application #
2735595
Study Section
Neurology B Subcommittee 2 (NEUB)
Program Officer
Oliver, Eugene J
Project Start
1991-12-01
Project End
2000-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
New York Medical College
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595

  Publications

Ma, Sherie; Hangya, Balázs; Leonard, Christopher S et al. (2018) Dual-transmitter systems regulating arousal, attention, learning and memory. Neurosci Biobehav Rev 85:21-33
Ishibashi, Masaru; Gumenchuk, Iryna; Miyazaki, Kenichi et al. (2016) Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization. J Neurosci 36:10097-115
Ishibashi, Masaru; Gumenchuk, Iryna; Kang, Bryan et al. (2015) Orexin Receptor Activation Generates Gamma Band Input to Cholinergic and Serotonergic Arousal System Neurons and Drives an Intrinsic Ca(2+)-Dependent Resonance in LDT and PPT Cholinergic Neurons. Front Neurol 6:120
Christensen, Mark H; Ishibashi, Masaru; Nielsen, Michael L et al. (2014) Age-related changes in nicotine response of cholinergic and non-cholinergic laterodorsal tegmental neurons: implications for the heightened adolescent susceptibility to nicotine addiction. Neuropharmacology 85:263-83
Leonard, C S; Kukkonen, J P (2014) Orexin/hypocretin receptor signalling: a functional perspective. Br J Pharmacol 171:294-313
Kukkonen, J P; Leonard, C S (2014) Orexin/hypocretin receptor signalling cascades. Br J Pharmacol 171:314-31
Kohlmeier, Kristi A; Tyler, Christopher J; Kalogiannis, Mike et al. (2013) Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy. Front Neurosci 7:246
Kohlmeier, Kristi A; Ishibashi, Masaru; Wess, Jurgen et al. (2012) Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus. J Neurophysiol 108:2751-66
Kalogiannis, Mike; Hsu, Emily; Willie, Jon T et al. (2011) Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice. PLoS One 6:e18697
Kalogiannis, M; Grupke, S L; Potter, P E et al. (2010) Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. Eur J Neurosci 32:130-42

Showing the most recent 10 out of 11 publications