This grant proposes a prospective longitudinal study of the seizure, psychiatric, neuropsychological, and vocational outcome of anterior temporal lobectomy (ATL) done for treatment of complex partial seizures of temporal lobe origin. ATL will be done by one surgical team but the patients will be randomized into two surgical groups. One patient group will have ATL done by a standard """"""""en bloc"""""""" resection. The other patient groups will have complex partial seizures with ictal onset from mesial temporal structures and will not have a causal structural lesion (i.e., tumor or AVM) documented by MRI scan. The outcome of study will: (1) help clarify the role of hippocampus in nonlesional temporal lobe epilepsy, and (2) help clarify the which of several methods of ATL produce the best seizure outcome with minimal psychological and psychiatric impairment to patients. This proposal apples directly to the conclusion of the recent NIH consensus conference of Epilepsy Surgery.
| Hermann, B P; Seidenberg, M; Schoenfeld, J et al. (1996) Empirical techniques for determining the reliability, magnitude, and pattern of neuropsychological change after epilepsy surgery. Epilepsia 37:942-50 |
| Wyler, A R; Hermann, B P; Somes, G (1995) Extent of medial temporal resection on outcome from anterior temporal lobectomy: a randomized prospective study. Neurosurgery 37:982-90;discussion 990-1 |
| Hermann, B P; Wyler, A R; Somes, G et al. (1994) Dysnomia after left anterior temporal lobectomy without functional mapping: frequency and correlates. Neurosurgery 35:52-6;discussion 56-7 |
| Hermann, B P (1993) Developing a model of quality of life in epilepsy: the contribution of neuropsychology. Epilepsia 34 Suppl 4:S14-21 |
| Hermann, B P; Wyler, A R; Somes, G et al. (1992) Pathological status of the mesial temporal lobe predicts memory outcome from left anterior temporal lobectomy. Neurosurgery 31:652-6;discussion 656-7 |
