Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS028791-04A2
Application #
2267188
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (01))
Project Start
1992-03-01
Project End
1999-06-30
Budget Start
1996-07-05
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Zhan, Ren-Zhi; Nadler, J Victor; Schwartz-Bloom, Rochelle D (2007) Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. J Cereb Blood Flow Metab 27:1444-52
Zhan, Ren-Zhi; Nadler, J Victor; Schwartz-Bloom, Rochelle D (2006) Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia. J Cereb Blood Flow Metab 26:112-24
Pond, Brooks B; Berglund, Ken; Kuner, Thomas et al. (2006) The chloride transporter Na(+)-K(+)-Cl- cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ischemia. J Neurosci 26:1396-406
Galeffi, Francesca; Sah, Renu; Pond, Brooks B et al. (2004) Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. J Neurosci 24:4478-88
Pond, Brooks B; Galeffi, Francesca; Ahrens, Rebecca et al. (2004) Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus. Neuropharmacology 47:253-62
Sah, Renu; Galeffi, Francesca; Ahrens, Rebecca et al. (2002) Modulation of the GABA(A)-gated chloride channel by reactive oxygen species. J Neurochem 80:383-91
Schwartz-Bloom, R D; Sah, R (2001) gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. J Neurochem 77:353-71
Schwartz-Bloom, R D; Miller, K A; Evenson, D A et al. (2000) Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study. Neuroscience 98:471-84
Galeffi, F; Sinnar, S; Schwartz-Bloom, R D (2000) Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia. J Neurochem 75:1242-9
Sah, R; Schwartz-Bloom, R D (1999) Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. J Neurosci 19:9209-17

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