Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS028792-07
Application #
2267193
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1990-08-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Virginia Polytechnic Institute and State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
003137015
City
Blacksburg
State
VA
Country
United States
Zip Code
24061
Castagnoli Jr, Neal; Castagnoli, Kay; Magnin, Geraldine et al. (2002) Studies on the oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines. Drug Metab Rev 34:533-47
Isin, E M; de Jonge, M; Castagnoli Jr, N (2001) Studies on synthetic approaches to 1H- and 2H-indazolyl derivatives. J Org Chem 66:4220-6
Kalgutkar, A S; Dalvie, D K; Castagnoli Jr, N et al. (2001) Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors. Chem Res Toxicol 14:1139-62
Kuttab, S; Shang, J; Castagnoli Jr, N (2001) Rat liver microsomal enzyme catalyzed oxidation of 4-phenyl-trans-1-(2-phenylcyclopropyl)-1,2,3,6-tetrahydropyridine. Bioorg Med Chem 9:1685-9
Petzer, J P; Bergh, J J; Mienie, L J et al. (2000) Metabolic defects caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and by HPTP (the tetrahydropyridinyl analog of haloperidol), in rats. Life Sci 66:1949-54
Nimkar, S K; Mabic, S; Anderson, A H et al. (1999) Studies on the monoamine oxidase-B-catalyzed biotransformation of 4-azaaryl-1-methyl-1,2,3,6-tetrahydropyridine derivatives. J Med Chem 42:1828-35
Mienie, L J; Bergh, J J; Bloomquist, J R et al. (1999) p-Fluorophenylglycine in the urine of baboons treated with HPTP, the tetrahydropyridine analog of haloperidol. Life Sci 65:535-42
Castagnoli, K; Palmer, S; Castagnoli Jr, N (1999) Neuroprotection by (R)-deprenyl and 7-nitroindazole in the MPTP C57BL/6 mouse model of neurotoxicity. Neurobiology (Bp) 7:135-49
Yu, J; Castagnoli Jr, N (1999) Synthesis and monoamine oxidase B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines. Bioorg Med Chem 7:2835-42
Yu, J; Castagnoli Jr, N (1999) Synthesis and MAO-B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines. Bioorg Med Chem 7:231-9

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