The objective of this proposal is to perform prospective longitudinal neurobehavioral follow-up studies of children ages 0-71 months who sustained either accidental (n=30) or nonaccidental (e.g., physical abuse traumatic brain injuries (n=30). A major challenge in studying developmental outcomes of child maltreatment is separation of the specific effects of maltreatment from the general effects of adverse socioenvironmental conditions. There are few studies of the role of CNS injury in physically abused children and little influence of environmental factors on cognitive and behavioral outcomes, comparison groups of children who (1) sustained physical abuse without CNS involvement (n=30) and (2) normal controls (n=30) will be evaluated. Intelligence, motor, receptive and expressive language, adaptive behavior, social competence, exploratory play, and behavioral disturbance will be evaluated during the initial hospitalization as well as 3 and 12 months following resolution of post-traumatic amnesia to determine the influence of cerebral injury on cognitive, social, and motor development. MRI will be obtained to document locus and type of CNS insult. Parental adjustment and a variety of environmental process variables will be evaluated to determine whether these variables moderate or buffer the effect of cerebral injury in very young children. Of particular interest is whether brain injury and adverse environmental circumstances have an additive or an interactive effect on development. This study will permit evaluation of (1) the relationship of neuropsychological outcome data to indices of acute and secondary brain injury; (2) the nature of impaired cognitive and behavioral functioning following accidental versus nonaccidental brain injury; (3) changes in the rate of skill development over time; (4) the influence of age at the time of brain injury on acute neuropathological findings and developmental outcome; and (5) family, and environmental data through a multidimensional model, the effects of accidental and nonaccidental head injury on the degree and rate of development can be addressed in the context of issues concerning recovery of function after early brain injury.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029462-04
Application #
2460532
Study Section
Special Emphasis Panel (ZRG1-HUD-1 (02))
Program Officer
Michel, Mary E
Project Start
1994-08-01
Project End
1999-07-31
Budget Start
1997-08-01
Budget End
1999-07-31
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Ewing-Cobbs, Linda; Bloom, Douglas R; Prasad, Mary R et al. (2014) Assessing recovery and disability after physical trauma: the Pediatric Injury Functional Outcome Scale. J Pediatr Psychol 39:653-65
Ewing-Cobbs, Linda; Prasad, Mary R; Mendez, Donna et al. (2013) Social interaction in young children with inflicted and accidental traumatic brain injury: relations with family resources and social outcomes. J Int Neuropsychol Soc 19:497-507
Ewing-Cobbs, Linda; Prasad, Mary R; Swank, Paul et al. (2012) Social communication in young children with traumatic brain injury: relations with corpus callosum morphometry. Int J Dev Neurosci 30:247-54
Ewing-Cobbs, Linda; Prasad, Mary R; Kramer, Larry et al. (2006) Late intellectual and academic outcomes following traumatic brain injury sustained during early childhood. J Neurosurg 105:287-96
Ewing-Cobbs, L; Hasan, K M; Prasad, M R et al. (2006) Corpus callosum diffusion anisotropy correlates with neuropsychological outcomes in twins disconcordant for traumatic brain injury. AJNR Am J Neuroradiol 27:879-81
Prasad, M R; Kramer, L A; Ewing-Cobbs, L (2005) Cognitive and neuroimaging findings in physically abused preschoolers. Arch Dis Child 90:82-5
Ewing-Cobbs, Linda; Prasad, Mary R; Landry, Susan H et al. (2004) Executive functions following traumatic brain injury in young children: a preliminary analysis. Dev Neuropsychol 26:487-512
Ewing-Cobbs, Linda; Barnes, Marcia; Fletcher, Jack M et al. (2004) Modeling of longitudinal academic achievement scores after pediatric traumatic brain injury. Dev Neuropsychol 25:107-33
Landry, Susan H; Swank, Paul; Stuebing, Karla et al. (2004) Social competence in young children with inflicted traumatic brain injury. Dev Neuropsychol 26:707-33
Ewing-Cobbs, Linda; Barnes, Marcia A; Fletcher, Jack M (2003) Early brain injury in children: development and reorganization of cognitive function. Dev Neuropsychol 24:669-704

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