Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029585-03
Application #
2267721
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1992-01-01
Project End
1995-12-31
Budget Start
1994-01-01
Budget End
1995-12-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Kordower, J H; Chen, E Y; Mufson, E J et al. (1996) Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: trophic effects upon cholinergic and noncholinergic striatal neurons. Neuroscience 72:63-77
Emerich, D F; Winn, S R; Harper, J et al. (1994) Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons. J Comp Neurol 349:148-64
Kordower, J H; Charles, V; Bayer, R et al. (1994) Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease. Proc Natl Acad Sci U S A 91:9077-80
Burke, M A; Apter, J R; Wainer, B H et al. (1994) Age-related vulnerability of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus. Exp Neurol 128:159-71
Kordower, J H; Chen, E Y; Sladek Jr, J R et al. (1994) trk-immunoreactivity in the monkey central nervous system: forebrain. J Comp Neurol 349:20-35
Kordower, J H; Mufson, E J (1993) NGF receptor (p75)-immunoreactivity in the developing primate basal ganglia. J Comp Neurol 327:359-75
Kordower, J H; Mufson, E J; Granholm, A C et al. (1993) Delivery of trophic factors to the primate brain. Exp Neurol 124:21-30
Kordower, J H; Mufson, E J (1992) Nerve growth factor receptor-immunoreactive neurons within the developing human cortex. J Comp Neurol 323:25-41