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Dryhurst, G (2001) Are dopamine, norepinephrine, and serotonin precursors of biologically reactive intermediates involved in the pathogenesis of neurodegenerative brain disorders? Adv Exp Med Biol 500:373-96
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Shen, X M; Li, H; Dryhurst, G (2000) Oxidative metabolites of 5-S-cysteinyldopamine inhibit the alpha-ketoglutarate dehydrogenase complex: possible relevance to the pathogenesis of Parkinson's disease. J Neural Transm 107:959-78
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Shen, X M; Dryhurst, G (1998) Iron- and manganese-catalyzed autoxidation of dopamine in the presence of L-cysteine: possible insights into iron- and manganese-mediated dopaminergic neurotoxicity. Chem Res Toxicol 11:824-37
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Li, H; Shen, X M; Dryhurst, G (1998) Brain mitochondria catalyze the oxidation of 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1) to intermediates that irreversibly inhibit complex I and scavenge glutathione: potential relevance to the pathogenesis of J Neurochem 71:2049-62
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Shen, X M; Zhang, F; Dryhurst, G (1997) Oxidation of dopamine in the presence of cysteine: characterization of new toxic products. Chem Res Toxicol 10:147-55
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Li, H; Dryhurst, G (1997) Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease. J Neurochem 69:1530-41
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