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Sheline, Christian T; Zhu, Julia; Zhang, Wendy et al. (2013) Mitochondrial inhibitor models of Huntington's disease and Parkinson's disease induce zinc accumulation and are attenuated by inhibition of zinc neurotoxicity in vitro or in vivo. Neurodegener Dis 11:49-58
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Carter, Russell E; Aiba, Isamu; Dietz, Robert M et al. (2011) Spreading depression and related events are significant sources of neuronal Zn2+ release and accumulation. J Cereb Blood Flow Metab 31:1073-84
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Sheline, Christian T; Cai, Ai-Li; Zhu, Julia et al. (2010) Serum or target deprivation-induced neuronal death causes oxidative neuronal accumulation of Zn2+ and loss of NAD+. Eur J Neurosci 32:894-904
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Suh, Sang Won; Won, Seok Joon; Hamby, Aaron M et al. (2009) Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J Cereb Blood Flow Metab 29:1579-88
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Cai, Ai-Li; Zipfel, Gregory J; Sheline, Christian T (2006) Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway. Eur J Neurosci 24:2169-76
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Sheline, C T; Wei, L (2006) Free radical-mediated neurotoxicity may be caused by inhibition of mitochondrial dehydrogenases in vitro and in vivo. Neuroscience 140:235-46
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Sheline, Christian T; Choi, Dennis W (2004) Cu2+ toxicity inhibition of mitochondrial dehydrogenases in vitro and in vivo. Ann Neurol 55:645-53
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Sheline, Christian T; Takata, Toshihiro; Ying, Howard et al. (2004) Potassium attenuates zinc-induced death of cultured cortical astrocytes. Glia 46:18-27
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Snider, B J; Moss, J L; Revilla, F J et al. (2003) Neocortical neurons cultured from mice with expanded CAG repeats in the huntingtin gene: unaltered vulnerability to excitotoxins and other insults. Neuroscience 120:617-25
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Sheline, Christian T; Wang, Hongmin; Cai, Ai-Li et al. (2003) Involvement of poly ADP ribosyl polymerase-1 in acute but not chronic zinc toxicity. Eur J Neurosci 18:1402-9
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