Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS030882-04
Application #
2268853
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1992-07-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Pharmacology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Tran, John A; Matsui, Minoru; Ehlert, Frederick J (2006) Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse. J Pharmacol Exp Ther 318:649-56
Griffin, Michael T; Matsui, Minoru; Shehnaz, Darakhshanda et al. (2004) Muscarinic agonist-mediated heterologous desensitization in isolated ileum requires activation of both muscarinic M2 and M3 receptors. J Pharmacol Exp Ther 308:339-49
Ehlert, Frederick J (2003) Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life Sci 74:355-66
Griffin, Michael T; Hsu, Jake Ching-Hsuan; Shehnaz, Darakhshanda et al. (2003) Comparison of the pharmacological antagonism of M2 and M3 muscarinic receptors expressed in isolation and in combination. Biochem Pharmacol 65:1227-41
Matsui, Minoru; Griffin, Michael T; Shehnaz, Darakhshanda et al. (2003) Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice. J Pharmacol Exp Ther 305:106-13
Ehlert, F J; Ansari, K Z; Shehnaz, D et al. (2001) Acetylcholine-induced desensitization of muscarinic contractile response in Guinea pig ileum is inhibited by pertussis toxin treatment. J Pharmacol Exp Ther 299:1126-32
Shehnaz, D; Ansari, K Z; Ehlert, F J (2001) Acetylcholine-induced desensitization of the contractile response to histamine in Guinea pig ileum is prevented by either pertussis toxin treatment or by selective inactivation of muscarinic M(3) receptors. J Pharmacol Exp Ther 297:1152-9
Sawyer, G W; Lambrecht, G; Ehlert, F J (2000) Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum. Br J Pharmacol 129:1458-64
Sawyer, G W; Ehlert, F J (1999) Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions. J Pharmacol Exp Ther 289:464-76
Ehlert, F J; Sawyer, G W; Esqueda, E E (1999) Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle. Life Sci 64:387-94

Showing the most recent 10 out of 26 publications