This application seeks to investigate relationships between changes in the biophysical environment of water and focal cerebral ischemia using Nuclear Magnetic Resonance (NMR). The degree and duration of reductions in regional cerebral blood flow (rCBF) and a well defined biological end- point of tissue damage will be characterized in terms of NMR-measurable parameters in a rat model of stroke (middle cerebral artery occlusion). The 1H NMR-measurable parameters of water (T1, T2, p and ADCw), are sensitive to changes in the biophysical environment of water (i.e., rotation, translation, concentration). NMR imaging will be used to characterize the spatial distribution and temporal evolution of changes in the biophysical environment of water. Additionally, a mechanism for the ischemia-induced reduction in the apparent diffusion coefficient of water (ADCw) will be [investigated]. It is proposed that an understanding of changes in the biophysical environment of water will lead to a better understanding of the mechanisms involved in ischemic brain damage. This approach may eventually provide a means for the non- invasive determination of the degree, severity, and status of stroke induced brain damage in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS030899-02
Application #
2268877
Study Section
Neurology A Study Section (NEUA)
Project Start
1993-09-22
Project End
1996-09-21
Budget Start
1994-09-22
Budget End
1995-09-21
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Nathan Kline Institute for Psychiatric Research
Department
Type
DUNS #
167204762
City
Orangeburg
State
NY
Country
United States
Zip Code
10962
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