Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS031238-04
Application #
2269176
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1992-12-01
Project End
2000-11-30
Budget Start
1995-12-15
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Surgery
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Tseng, Elaine E; Brock, Malcolm V; Lange, Mary S et al. (2010) Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg 89:440-5
Shake, J G; Peck, E A; Marban, E et al. (2001) Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection. Ann Thorac Surg 72:1849-54
Tseng, E E; Brock, M V; Lange, M S et al. (1999) Nitric oxide mediates neurologic injury after hypothermic circulatory arrest. Ann Thorac Surg 67:65-71
Tseng, E E; Brock, M V; Kwon, C C et al. (1999) Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest. Ann Thorac Surg 67:371-6
Baumgartner, W A; Walinsky, P L; Salazar, J D et al. (1999) Assessing the impact of cerebral injury after cardiac surgery: will determining the mechanism reduce this injury? Ann Thorac Surg 67:1871-3;discussion 1891-4
Lange, M S; Johnston, M V; Tseng, E E et al. (1999) Apoptosis detection in brain using low-magnification dark-field microscopy. Exp Neurol 158:254-60
Tseng, E E; Brock, M V; Lange, M S et al. (1998) Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest. Surgery 124:298-306
Baumgartner, W A; Redmond, J M; Zehr, K J et al. (1998) The role of the monosialoganglioside, GM1 as a neuroprotectant in an experimental model of cardiopulmonary bypass and hypothermic circulatory arrest. Ann N Y Acad Sci 845:382-90
Baumgartner, W A; Redmond, M; Brock, M et al. (1997) Pathophysiology of cerebral injury and future management. J Card Surg 12:300-10; discussion 310-1
Tseng, E E; Brock, M V; Lange, M S et al. (1997) Neuronal nitric oxide synthase inhibition reduces neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg 64:1639-47

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