Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS031519-04
Application #
2269449
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1993-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Utah
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Bamber, Bruce A; Twyman, Roy E; Jorgensen, Erik M (2003) Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans. Br J Pharmacol 138:883-93
Twyman, R E; Rogers, S W; Gahring, L C et al. (1999) Antibodies to glutamate receptors: a role in excitatory dysregulation of the central nervous system? Adv Neurol 79:535-41
Bamber, B A; Beg, A A; Twyman, R E et al. (1999) The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor. J Neurosci 19:5348-59
McClellan, A M; Twyman, R E (1999) Receptor system response kinetics reveal functional subtypes of native murine and recombinant human GABAA receptors. J Physiol 515 ( Pt 3):711-27
Donevan, S D; Beg, A; Gunther, J M et al. (1998) The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J Pharmacol Exp Ther 285:539-45
Lavoie, A M; Tingey, J J; Harrison, N L et al. (1997) Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform. Biophys J 73:2518-26
Gahring, L C; Rogers, S W; Twyman, R E (1997) Autoantibodies to glutamate receptor subunit GluR2 in nonfamilial olivopontocerebellar degeneration. Neurology 48:494-500
Lavoie, A M; Twyman, R E (1996) Direct evidence for diazepam modulation of GABAA receptor microscopic affinity. Neuropharmacology 35:1383-92
Twyman, R E; Gahring, L C; Spiess, J et al. (1995) Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site. Neuron 14:755-62
Skeen, G A; White, H S; Twyman, R E (1994) The dihydropyridine nitrendipine reduces N-methyl-D-aspartate (NMDA)-evoked currents of rodent cortical neurons through a direct interaction with the NMDA receptor-associated ion channel. J Pharmacol Exp Ther 271:30-8