Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS032630-03
Application #
2270954
Study Section
Neurology C Study Section (NEUC)
Program Officer
Kerza-Kwiatecki, a P
Project Start
1994-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Walker, W S (1999) Separate precursor cells for macrophages and microglia in mouse brain: immunophenotypic and immunoregulatory properties of the progeny. J Neuroimmunol 94:127-33
Havenith, C E; Askew, D; Walker, W S (1998) Mouse resident microglia: isolation and characterization of immunoregulatory properties with naive CD4+ and CD8+ T-cells. Glia 22:348-59
Sun, D; Whitaker, J N; Cao, L et al. (1998) Cell death mediated by Fas-FasL interaction between glial cells and MBP-reactive T cells. J Neurosci Res 52:458-67
Walker, W S; Castrucci, M R; Sangster, M Y et al. (1997) HEL-Flu: an influenza virus containing the hen egg lysozyme epitope recognized by CD4+ T cells from mice transgenic for an alphabeta TCR. J Immunol 159:2563-6
Sun, D; Hu, X; Liu, X et al. (1997) Expression of chemokine genes in rat glial cells: the effect of myelin basic protein-reactive encephalitogenic T cells. J Neurosci Res 48:192-200
Askew, D; Havenith, C E; Walker, W S (1996) Heterogeneity of mouse brain macrophages in alloantigen presentation to naive CD8+ T cells as revealed by a panel of microglial cell lines. Immunobiology 195:417-30
Askew, D; Walker, W S (1996) Alloantigen presentation to naive CD8+ T cells by mouse microglia: evidence for a distinct phenotype based on expression of surface-associated and soluble costimulatory molecules. Glia 18:118-28
Walker, W S; Gatewood, J; Olivas, E et al. (1995) Mouse microglial cell lines differing in constitutive and interferon-gamma-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells. J Neuroimmunol 63:163-74
Askew, D; Gatewood, J; Olivas, E et al. (1995) A subset of splenic macrophages process and present native antigen to naive antigen-specific CD4+ T-cells from mice transgenic for an alpha beta T-cell receptor. Cell Immunol 166:62-70
Olivas, E; Chen, B B; Walker, W S (1995) Use of the Pannell-Milstein roller bottle apparatus to produce high concentrations of the CSF-1, the mouse macrophage growth factor. J Immunol Methods 182:73-9