Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS033290-02
Application #
2272005
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1995-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Biomedical Engineering
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Muppirala, Usha K; Desensi, Susan; Lybrand, Terry P et al. (2009) Molecular modeling of flexible arm-mediated interactions between bacterial chemoreceptors and their modification enzyme. Protein Sci 18:1702-14
Furse, Kristina E; Pratt, Derek A; Porter, Ned A et al. (2006) Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behavior. Biochemistry 45:3189-205
Lai, Wing-Cheung; Peach, Megan L; Lybrand, Terry P et al. (2006) Diagnostic cross-linking of paired cysteine pairs demonstrates homologous structures for two chemoreceptor domains with low sequence identity. Protein Sci 15:94-101
Furse, Kristina E; Pratt, Derek A; Schneider, Claus et al. (2006) Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity. Biochemistry 45:3206-18
Moth, Christopher W; Prusakiewicz, Jeffrey J; Marnett, Larry J et al. (2005) Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1. J Med Chem 48:3613-20
Hata, Aaron N; Lybrand, Terry P; Breyer, Richard M (2005) Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2. J Biol Chem 280:32442-51
Hata, Aaron N; Lybrand, Terry P; Marnett, Lawrence J et al. (2005) Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. Mol Pharmacol 67:640-7
Harikumar, Kaleeckal G; Pinon, Delia I; Wessels, William S et al. (2004) Measurement of intermolecular distances for the natural agonist Peptide docked at the cholecystokinin receptor expressed in situ using fluorescence resonance energy transfer. Mol Pharmacol 65:28-35
Dong, Maoqing; Li, Zhijun; Pinon, Delia I et al. (2004) Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor. J Biol Chem 279:2894-903
Zang, Mengwei; Dong, Maoqing; Pinon, Delia I et al. (2003) Spatial approximation between a photolabile residue in position 13 of secretin and the amino terminus of the secretin receptor. Mol Pharmacol 63:993-1001

Showing the most recent 10 out of 22 publications