Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS033296-03
Application #
2272015
Study Section
Pathology A Study Section (PTHA)
Project Start
1994-07-11
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Barkalow, F J; Barkalow, K L; Mayadas, T N (2000) Dimerization of P-selectin in platelets and endothelial cells. Blood 96:3070-7
Rosenkranz, A R; Mendrick, D L; Cotran, R S et al. (1999) P-selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P-selectin in inflammation. J Clin Invest 103:649-59
Bhat, N; Perera, P Y; Carboni, J M et al. (1999) Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression. J Immunol 162:7335-42
Soriano, S G; Coxon, A; Wang, Y F et al. (1999) Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke 30:134-9
Rosenkranz, A R; Coxon, A; Maurer, M et al. (1998) Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice. J Immunol 161:6463-7
Hartwell, D W; Mayadas, T N; Berger, G et al. (1998) Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. J Cell Biol 143:1129-41
Tang, T; Rosenkranz, A; Assmann, K J et al. (1997) A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J Exp Med 186:1853-63
Coxon, A; Rieu, P; Barkalow, F J et al. (1996) A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5:653-66
Tang, T; Frenette, P S; Hynes, R O et al. (1996) Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J Clin Invest 97:2485-90
Mayadas, T N; Mendrick, D L; Brady, H R et al. (1996) Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. Kidney Int 49:1342-9

Showing the most recent 10 out of 12 publications