The Denny-Brown collection consists of approximately 2700 films depicting specific behaviors of monkeys subsequent to lesions of major central nervous system structures and regions, and the behavior of patients with neurological diseases. The collection includes associated written records, histological slides and photographs of the brains of the monkeys at autopsy. Our prior work with this collection, which was compiled by the late world-renowned neurologist, Derek E. Denny-Brown, primarily involved publicizing its availability, converting all the filmed images to videotape, and editing the tapes so that a single tape contains all the images from one animal arranged in sequential order. Additionally, we have used the patient films to develop verbally annotated videotapes designed for teaching students about neurological disorders, some of which are no longer seen (e.g., postencephalitic parkinsonism). For the present project, in addition to continuing to publicize and utilize the collection, we propose to develop a computerized database that will greatly increase the utility of the collection by making it searchable by lesion and/or specific behavior. Thus, the investigators will easily be able to determine the particular cases in the collection that contain images that would be useful to their individual research interests.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS033782-03
Application #
2502974
Study Section
Neurology A Study Section (NEUA)
Program Officer
Oliver, Eugene J
Project Start
1995-01-01
Project End
2000-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
Organized Research Units
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Vilensky, J A; Gilman, S (2001) Integrating the work of D. Denny-Brown and some of his contemporaries into current studies of the primate motor cortex. J Neurol Sci 182:83-7
Vilensky, J A; Barnhart, S W; Gilman, S et al. (1999) Disorders of proprioceptive responses in monkeys after cerebellar lesions: an analysis using the Denny-Brown Collection. J Neurol Sci 163:111-8
Gilman, S; Vilensky, J A; Morecraft, R W et al. (1999) Denny-Brown's views on the pathophysiology of dystonia. J Neurol Sci 167:142-7
Vilensky, J A; Morecraft, R J; Gilman, S et al. (1998) 'Mouth-feeding' in monkeys after sensorimotor system lesions: an analysis based upon the Denny-Brown collection. Behav Brain Res 94:311-5
Vilensky, J A; Gilman, S (1997) Positive and negative factors in movement control: a current review of Denny-Brown's hypothesis. J Neurol Sci 151:149-58
Vilensky, J A; Gilman, S; Dunn, E A et al. (1997) Utilization of the Denny-Brown collection: differential recovery of forelimb and hind limb stepping after extensive unilateral cerebral lesions. Behav Brain Res 82:223-33
Vilensky, J A; Gilman, S (1996) The Denny-Brown collection: useful resource for physical therapy practitioners and educators. Phys Ther 76:890-3
Vilensky, J A; Gilman, S; Morecraft, R J (1996) DC60: an example of one of the 450 cases that compose the Denny-Brown collection of primate lesion material. Mov Disord 11:207-13
Vilensky, J A; Gilman, S (1996) Utilization of available films and records of primates with central nervous system lesions. Folia Primatol (Basel) 66:204-8