Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS034025-01A2
Application #
2037931
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (01))
Project Start
1996-09-30
Project End
2000-07-31
Budget Start
1996-09-30
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Cook, Robert G; Geller, Alfred I; Zhang, Guo-Rong et al. (2004) Touchscreen-enhanced visual learning in rats. Behav Res Methods Instrum Comput 36:101-6
Tang, J; Yang, T; Ghosh, H P et al. (2001) Helper virus-free HSV-1 vectors packaged both in the presence of VSV G protein and in the absence of HSV-1 glycoprotein B support gene transfer into neurons in the rat striatum. J Neurovirol 7:548-55
Neill, J C; Sarkisian, M R; Wang, Y et al. (2001) Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons. Brain Res Mol Brain Res 93:127-36
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Sun, M; Lee, J; Yu, L et al. (2000) Modest increases in the titers of helper virus-free herpes simplex virus 1 (HSV-1) vectors by packaging in a cell line with inducible expression of HSV-1 VP16 or by treatment with N,N'-hexamethylene-bis-acetamide. Acta Virol 44:365-9
Wang, Y; Yu, L; Geller, A I (1999) Diverse stabilities of expression in the rat brain from different cellular promoters in a helper virus-free herpes simplex virus type 1 vector system. Hum Gene Ther 10:1763-71
Geller, A I (1999) Genetic analysis of the role of protein kinase C signaling pathways in behaviors by direct gene transfer with HSV-1 vectors. Rev Neurosci 10:1-13
Sun, M; Zhang, G R; Yang, T et al. (1999) Improved titers for helper virus-free herpes simplex virus type 1 plasmid vectors by optimization of the packaging protocol and addition of noninfectious herpes simplex virus-related particles (previral DNA replication enveloped particles) to the packagin Hum Gene Ther 10:2005-11
Kong, Y; Yang, T; Geller, A I (1999) An efficient in vivo recombination cloning procedure for modifying and combining HSV-1 cosmids. J Virol Methods 80:129-36
Lewandowski, G; Hobbs, M; Geller, A (1998) Evidence that deficient IFN-gamma production is a biological basis of herpes simplex virus type-2 neurovirulence. J Neuroimmunol 81:66-75

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