Mutant Sod 1 Transduced Spinal Neurons - A Model of Als

Figlewicz, Denise A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS034101-02
• Application #: 2273221
• Study Section: Neurology C Study Section (NEUC)
• Project Start: 1995-05-01
• Project End: 1998-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of Rochester
• Department: Neurology
• Type: Schools of Dentistry
• DUNS #: 208469486
• City: Rochester
• State: NY
• Country: United States
• Zip Code: 14627

Publications

Derby, M L; Giuliano, R; Figlewicz, D A et al. (2000) GDNF is trophic for mouse motoneurons that express a mutant superoxide dismutase (SOD-1) gene. Amyotroph Lateral Scler Other Motor Neuron Disord 1:113-22

Mohajeri, M H; Figlewicz, D A; Bohn, M C (1999) Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis. Hum Gene Ther 10:1853-66

Mohajeri, M H; Figlewicz, D A; Bohn, M C (1998) Selective loss of alpha motoneurons innervating the medial gastrocnemius muscle in a mouse model of amyotrophic lateral sclerosis. Exp Neurol 150:329-36