Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS034138-02
Application #
2273267
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1995-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Devinney, Michael J; Malaiyandi, Latha M; Vergun, Olga et al. (2009) A comparison of Zn2+- and Ca2+-triggered depolarization of liver mitochondria reveals no evidence of Zn2+-induced permeability transition. Cell Calcium 45:447-55
Dineley, Kirk E; Devinney 2nd, Michael J; Zeak, Jennifer A et al. (2008) Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation. J Neurochem 106:2184-93
Malaiyandi, Latha M; Vergun, Olga; Dineley, Kirk E et al. (2005) Direct visualization of mitochondrial zinc accumulation reveals uniporter-dependent and -independent transport mechanisms. J Neurochem 93:1242-50
Malaiyandi, Latha M; Honick, Anthony S; Rintoul, Gordon L et al. (2005) Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation. J Neurosci 25:9507-14
Devinney 2nd, Michael J; Reynolds, Ian J; Dineley, Kirk E (2005) Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3. Cell Calcium 37:225-32
Dineley, Kirk E; Richards, Lauren L; Votyakova, Tatyana V et al. (2005) Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria. Mitochondrion 5:55-65
Malaiyandi, Latha M; Dineley, Kirk E; Reynolds, Ian J (2004) Divergent consequences arise from metallothionein overexpression in astrocytes: zinc buffering and oxidant-induced zinc release. Glia 45:346-53
Dineley, Kirk E; Votyakova, Tatyana V; Reynolds, Ian J (2003) Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration. J Neurochem 85:563-70
Dineley, K E; Brocard, J B; Reynolds, I J (2002) Elevated intracellular zinc and altered proton homeostasis in forebrain neurons. Neuroscience 114:439-49
Kress, Geraldine J; Dineley, Kirk E; Reynolds, Ian J (2002) The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes. J Neurosci 22:5848-55

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