Role of Complement Activation in Alzheimer's Disease

Cooper, Neil R.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS034682-03
• Application #: 2735680
• Study Section: Neurological Sciences Subcommittee 1 (NLS)
• Program Officer: Murphy, Diane
• Project Start: 1996-07-01
• Project End: 2000-06-30
• Budget Start: 1998-07-01
• Budget End: 2000-06-30
• Support Year: 3
• Fiscal Year: 1998

Institution

• Name: Scripps Research Institute
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Yu, Jack X; Bradt, Bonnie M; Cooper, Neil R (2002) Constitutive expression of proinflammatory complement components by subsets of neurons in the central nervous system. J Neuroimmunol 123:91-101

Cooper, N R; Bradt, B M; O'Barr, S et al. (2000) Focal inflammation in the brain: role in Alzheimer's disease. Immunol Res 21:159-65

O'Barr, S; Cooper, N R (2000) The C5a complement activation peptide increases IL-1beta and IL-6 release from amyloid-beta primed human monocytes: implications for Alzheimer's disease. J Neuroimmunol 109:87-94

Bradt, B M; Kolb, W P; Cooper, N R (1998) Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. J Exp Med 188:431-8

Webster, S; Bradt, B; Rogers, J et al. (1997) Aggregation state-dependent activation of the classical complement pathway by the amyloid beta peptide. J Neurochem 69:388-98

Webster, S; Lue, L F; Brachova, L et al. (1997) Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease. Neurobiol Aging 18:415-21