Abstract

Neurotrophins play an essential role in the production, survival and maintenance of neurons in peripheral nerve ganglia. However, little is known about the impact of neurotrophins on the actual innervation of the skin where the full range of neuronal phenotypes and target selection are expressed. The wide variety of organized sensory and autonomic endings in the mystacial pad will be used in an assay to test several hypotheses about neurotrophin signaling mechanisms. These hypotheses are based on several important and surprising observations about the impact of null mutations and overexpression of neurotrophins in skin. The PI now plans to determine neurotrophin receptor expressions for each of the developing sets of innervation to the normal mouse and rat mystacial pad. Neurotrophin receptor expression will also be studied in mice with null mutations for neurotrophins and their receptors and in transgenic mice overexpressing neurotrophins in the skin. The impact of NGF and NT-3 overexpression on sensory and sympathetic endings will be assessed. Finally, the role of p75 in mediating the dramatic suppression of terminal arborization mediated by BDNF will be assessed. These studies should enhance our understanding of the role of neurotrophins and their receptors in regulating the development of specific types cutaneous innervation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS034692-02
Application #
2892023
Study Section
Neurology B Subcommittee 2 (NEUB)
Program Officer
Nichols, Paul L
Project Start
1998-04-01
Project End
2002-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Albany Medical College
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12208

  Publications

Sarko, Diana K; Rice, Frank L; Reep, Roger L (2015) Elaboration and Innervation of the Vibrissal System in the Rock Hyrax (Procavia capensis). Brain Behav Evol 85:170-88
Zhao, Peng; Barr, Travis P; Hou, Quanzhi et al. (2008) Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain. Pain 139:90-105
Cannon, Keri E; Chazot, Paul L; Hann, Victoria et al. (2007) Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: potential antinociceptive targets. Pain 129:76-92
Sarko, Diana K; Reep, Roger L; Mazurkiewicz, Joseph E et al. (2007) Adaptations in the structure and innervation of follicle-sinus complexes to an aquatic environment as seen in the Florida manatee (Trichechus manatus latirostris). J Comp Neurol 504:217-37
Albrecht, Phillip J; Hines, Scott; Eisenberg, Elon et al. (2006) Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome. Pain 120:244-66
Ibrahim, Mohab M; Porreca, Frank; Lai, Josephine et al. (2005) CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A 102:3093-8
Zylka, Mark J; Rice, Frank L; Anderson, David J (2005) Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 45:17-25
Funfschilling, Ursula; Ng, Yu-Gie; Zang, Keling et al. (2004) TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. J Comp Neurol 480:392-414
Guha, Udayan; Gomes, William A; Samanta, Jayshree et al. (2004) Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo. Development 131:1175-86
Hiran, Tejindervir S; Mazurkiewicz, Joseph E; Kreienberg, Paul et al. (2003) Endothelial expression of the alpha6beta4 integrin is negatively regulated during angiogenesis. J Cell Sci 116:3771-81

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