Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS035098-01
Application #
2274429
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Program Officer
Kitt, Cheryl A
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Krasnoperov, Valery; Deyev, Igor E; Serova, Oxana V et al. (2009) Dissociation of the subunits of the calcium-independent receptor of alpha-latrotoxin as a result of two-step proteolysis. Biochemistry 48:3230-8
Krasnoperov, Valery; Bittner, Mary A; Mo, Wenjun et al. (2002) Protein-tyrosine phosphatase-sigma is a novel member of the functional family of alpha-latrotoxin receptors. J Biol Chem 277:35887-95
Krasnoperov, Valery; Lu, Yun; Buryanovsky, Leonid et al. (2002) Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) moti J Biol Chem 277:46518-26
Hlubek, M D; Stuenkel, E L; Krasnoperov, V G et al. (2000) Calcium-independent receptor for alpha-latrotoxin and neurexin 1alpha [corrected] facilitate toxin-induced channel formation: evidence that channel formation results from tethering of toxin to membrane. Mol Pharmacol 57:519-28
Krasnoperov, V; Bittner, M A; Holz, R W et al. (1999) Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion. A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants. J Biol Chem 274:3590-6
Ichtchenko, K; Bittner, M A; Krasnoperov, V et al. (1999) A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors. J Biol Chem 274:5491-8
Bittner, M A; Krasnoperov, V G; Stuenkel, E L et al. (1998) A Ca2+-independent receptor for alpha-latrotoxin, CIRL, mediates effects on secretion via multiple mechanisms. J Neurosci 18:2914-22
Geppert, M; Khvotchev, M; Krasnoperov, V et al. (1998) Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J Biol Chem 273:1705-10
Krasnoperov, V G; Bittner, M A; Beavis, R et al. (1997) alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron 18:925-37
Krasnoperov, V G; Beavis, R; Chepurny, O G et al. (1996) The calcium-independent receptor of alpha-latrotoxin is not a neurexin. Biochem Biophys Res Commun 227:868-75