Mechanism of Action of Botulinum Neurotoxin

Schengrund, Cara-Lynne

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 1R01NS035653-01
• Application #: 2274893
• Study Section: Neurological Sciences Subcommittee 1 (NLS)
• Program Officer: Kitt, Cheryl A
• Project Start: 1996-09-01
• Project End: 1999-07-31
• Budget Start: 1996-09-01
• Budget End: 1997-07-31
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: Pennsylvania State University
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 129348186
• City: Hershey
• State: PA
• Country: United States
• Zip Code: 17033

Publications

Yowler, Brian C; Kensinger, Richard D; Schengrund, Cara-Lynne (2002) Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I. J Biol Chem 277:32815-9

Yowler, B C; Stoehr, S A; Schengrund, C L (2001) Oxidation and base-catalyzed elimination of the saccharide portion of GSLs having very different polarities. J Lipid Res 42:659-62

Jurasinski, C V; Lieth, E; Dang Do, A N et al. (2001) Correlation of cleavage of SNAP-25 with muscle function in a rat model of Botulinum neurotoxin type A induced paralysis. Toxicon 39:1309-15

Schengrund, C L; Kovac, P (1999) UDP-6-deoxy-6-fluoro-alpha-D-galactose binds to two different galactosyltransferases, but neither can effectively catalyze transfer of the modified galactose to the appropriate acceptor. Carbohydr Res 319:24-8

Schengrund, C L; Kovac, P (1999) A simple, nonenzymatic method for desialylating polysialylated ganglio-N-tetraose series gangliosides to produce GM1. J Lipid Res 40:160-3

Thompson, J P; Schengrund, C L (1998) Inhibition of the adherence of cholera toxin and the heat-labile enterotoxin of Escherichia coli to cell-surface GM1 by oligosaccharide-derivatized dendrimers. Biochem Pharmacol 56:591-7