The distinction between a ventral visual processing stream devoted to processing object identity and a dorsal stream coding object location and body movements guides two decades of research in perception and action. A number of lines of evidence, including work from our laboratory, suggest that the model requires refinement. This work described in this proposal has two general aims. The first is to develop a model of the action system within a computational framework. The model includes two anatomically and functionally distinct components: the action representation system, mediated by the inferior parietal lobe, and the action execution system, mediated by dorsal stream structures in fronto-parietal cortex. The second general aim is to reconcile a major clinical syndrome, ideomotor apraxia (IM), with recent advances in the cognitive neuroscientific study of action. There are four specific aims. First, we will relate the diverse presentation of IM to the two components of the action system by evaluating a two-subtype model of lM. Second, through study of patients with IM, we will assess the distinction between two types of spatial coding of body position and body movement information. Third, we will assess the roles of objects in performing skilled movements, and the distinctions between object representations used in different contexts. Finally, we will elucidate internal models of movement used in programming actions. The proposed program of research is expected to continue to contribute to our understanding of the relationship of distinct representational and dynamic processing modules in normal and disordered action, and the neuroanatomic substrate for these processes. In addition, it is expected to significantly advance our understanding of lM, a common clinical disorder whose presentation, subtypes, and neuroanatomic substrate remain poorly understood. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS036387-09
Application #
7103609
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Babcock, Debra J
Project Start
1997-02-01
Project End
2010-06-30
Budget Start
2008-09-01
Budget End
2010-06-30
Support Year
9
Fiscal Year
2006
Total Cost
$325,614
Indirect Cost
Name
Albert Einstein Medical Center (Philadelphia)
Department
Type
DUNS #
148406911
City
Philadelphia
State
PA
Country
United States
Zip Code
19141
Jax, Steven A; Buxbaum, Laurel J (2013) Response interference between functional and structural object-related actions is increased in patients with ideomotor apraxia. J Neuropsychol 7:12-8
Palluel-Germain, Richard; Jax, Steven A; Buxbaum, Laurel J (2011) Visuo-motor gain adaptation and generalization following left hemisphere stroke. Neurosci Lett 498:222-6
Buxbaum, Laurel J; Kalénine, Solène (2010) Action knowledge, visuomotor activation, and embodiment in the two action systems. Ann N Y Acad Sci 1191:201-18
Kalenine, Solene; Buxbaum, Laurel J; Coslett, Harry Branch (2010) Critical brain regions for action recognition: lesion symptom mapping in left hemisphere stroke. Brain 133:3269-80
Myung, Jong-yoon; Blumstein, Sheila E; Yee, Eiling et al. (2010) Impaired access to manipulation features in Apraxia: evidence from eyetracking and semantic judgment tasks. Brain Lang 112:101-12
Dawson, Amanda M; Buxbaum, Laurel J; Duff, Susan V (2010) The impact of left hemisphere stroke on force control with familiar and novel objects: neuroanatomic substrates and relationship to apraxia. Brain Res 1317:124-36
Jax, Steven A; Buxbaum, Laurel J (2010) Response interference between functional and structural actions linked to the same familiar object. Cognition 115:350-5
Botvinick, Matthew M; Buxbaum, Laurel J; Bylsma, Lauren M et al. (2009) Toward an integrated account of object and action selection: a computational analysis and empirical findings from reaching-to-grasp and tool-use. Neuropsychologia 47:671-83
Jax, Steven A; Buxbaum, Laurel J; Lie, Eunhui et al. (2009) More than (where the target) meets the eyes: disrupted visuomotor transformations in optic ataxia. Neuropsychologia 47:230-8
Buxbaum, Laurel J; Palermo, Mary Ann; Mastrogiovanni, Dina et al. (2008) Assessment of spatial attention and neglect with a virtual wheelchair navigation task. J Clin Exp Neuropsychol 30:650-60

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