The long-term objectives of this proposal are to understand the neurobiological basis of complex cognitive, perceptual and motor processes from the standpoint of neurophysiological and neuroanatomical specializations of the left and right cerebral hemispheres.
The aims are to evaluate neural systems involved in the expression of communicative behaviors, execution and perception of motor actions and social behaviors that are hypothesized to be homologs to the evolution of complex human cognition including expressive and receptive language. Positron emission tomography (PET) will be used to assess the neurobiology of gestural and vocal communication in chimpanzees. Additional PET studies will be conducted to evaluate whether the """"""""mirror-neuron"""""""" system of motor action and perception previously described in monkeys underlies the execution and perception of complex motor processes, such as imitation, in chimpanzees. PET studies will also be used to evaluate evolutionary hypotheses of language origins that are rooted in the social functions of language. Of specific interest is the link between the evolution of language and the function of social grooming in primates. To test these hypotheses, PET will be used to evaluate the neural systems involved in grooming by chimpanzees. The neurobiology of handedness, one of the most pronounced manifestations of hemispheric specialization, will also be evaluated in the proposed studies. PET will be used to assess where the hand is represented in the primary motor cortex in chimpanzees and these data will be mapped to known neuroanatomical landmarks on the motor strip of chimpanzees. Hand regions will then be mapped and quantifed in the left and right cerebral hemispheres from magnetic resonance images (MRI) and asymmetries in this region will be correlated with various measures of hand preference and skill. The overall studies will contribute to our understanding of factors that influence individual and species differences in the expression of hemispheric specialization.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS036605-07
Application #
7066115
Study Section
Cognitive Neuroscience Study Section (COG)
Program Officer
Babcock, Debra J
Project Start
2004-09-15
Project End
2008-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
7
Fiscal Year
2006
Total Cost
$319,023
Indirect Cost
Name
Emory University
Department
Type
Other Domestic Higher Education
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Weiss, Alexander; Staes, Nicky; Pereboom, Jeffrey J M et al. (2015) Personality in Bonobos. Psychol Sci 26:1430-9
Taglialatela, Jared P; Reamer, Lisa; Schapiro, Steven J et al. (2012) Social learning of a communicative signal in captive chimpanzees. Biol Lett 8:498-501
Taglialatela, Jared P; Russell, Jamie L; Schaeffer, Jennifer A et al. (2011) Chimpanzee vocal signaling points to a multimodal origin of human language. PLoS One 6:e18852
Leavens, David A; Russell, Jamie L; Hopkins, William D (2010) Multimodal communication by captive chimpanzees (Pan troglodytes). Anim Cogn 13:33-40
Hopkins, William D; Phillips, Kimberley A (2010) Cross-sectional analysis of the association between age and corpus callosum size in chimpanzees (Pan troglodytes). Dev Psychobiol 52:133-41
Hopkins, William D; Taglialatela, Jared P; Russell, Jamie L et al. (2010) Cortical representation of lateralized grasping in chimpanzees (Pan troglodytes): a combined MRI and PET study. PLoS One 5:e13383
Cantalupo, Claudio; Hopkins, William (2010) The cerebellum and its contribution to complex tasks in higher primates: a comparative perspective. Cortex 46:821-30
Meguerditchian, Adrien; Vauclair, Jacques; Hopkins, William D (2010) Captive chimpanzees use their right hand to communicate with each other: implications for the origin of the cerebral substrate for language. Cortex 46:40-8
Hopkins, William D; Nir, Talia M (2010) Planum temporale surface area and grey matter asymmetries in chimpanzees (Pan troglodytes): the effect of handedness and comparison with findings in humans. Behav Brain Res 208:436-43
Phillips, K A; Kapfenberger, N; Hopkins, W D (2009) A comparative study of corpus callosum size and signal intensity in capuchin monkeys (Cebus apella) and chimpanzees (Pan troglodytes). Neuroscience 159:1119-25

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