This application proposes to study functional MRI, structural MRI, and neuropsychological function in individuals at different levels of risk for Alzheimer's Disease. The risk groups will be defined by family history and by apolipoprotein-E allele status. The major hypothesis is that the pattern and extent of cortical activation during a visual confrontation naming task will differ substantially between subjects at high and low risk for AD. The investigators will also determine whether structural/anatomic differences exist between the groups and whether these MRI findings correlate with neuropsychological function. This application addresses a very important area in AD research. The preliminary fMRI data would be stronger if it included elderly subjects or these at risk for AD. The use of two different strategies for identifying intermediate risk groups may pose some difficulties and interpretation. The primary analyses of fMRI data is group mean data rather date released: 04/04/1997.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS036660-02
Application #
2714641
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Program Officer
Oliver, Eugene J
Project Start
1997-09-30
Project End
2000-05-31
Budget Start
1998-06-01
Budget End
1999-05-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Neurology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
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