The effects on the contralateral SI cortex of two different (non-noxious mechanical versus thermal) modes of natural skin stimulation will be studied in intact subjects, and also in subjects lacking either the spinal dorsal column or spinothalamic project pathways. Anesthetized squirrel monkeys will serve as subjects. In each subject a combination of the methods of near-infrared optical intrinsic signal (OIS) imaging and extracellular microelectrode recording will be used to obtain information about the SI neuron population and single neuron responses to the two modes of skin stimulation. In each subject recordings of the spike discharge activity evoke from single SI neurons by each model of skin stimulation. In each subject recordings of the spike discharge activity of the spike discharge activity evoked from single SI neurons by each mode of skin stimulation will be obtained from neurons located in functionally contrasting SI regions (e.g. regions in which the skin stimulus evokes increased vs. regions which undergo a decrease in activity. The microelectrode penetrations will be guided by high-resolution OIS images of the SI optical response to the same stimuli used to evoke single neuron discharge activity. In some experiments direct application of drugs to cerebral cortex or to spinal cord will be used to distinguish the contributions to the SI responses of activity in the NMDA receptor systems of cerebral cortex versus dorsal horn. The project is expected to generate novel information about the contributions of stimulus-directed cortico-cortical interactions to SI information processing and somesthesis. The findings also should bear on current theories of the CNS mechanisms of nonciception and pain

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS037501-03
Application #
6539980
Study Section
Special Emphasis Panel (ZRG1-IFCN-4 (01))
Program Officer
Edwards, Emmeline
Project Start
2000-04-01
Project End
2003-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
3
Fiscal Year
2002
Total Cost
$291,000
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Physiology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Lee, Jaekwang; Han, Young-Eun; Favorov, Oleg et al. (2016) Fluoride Induces a Volume Reduction in CA1 Hippocampal Slices Via MAP Kinase Pathway Through Volume Regulated Anion Channels. Exp Neurobiol 25:72-8
Lee, Jaekwang; Woo, Junsung; Favorov, Oleg V et al. (2012) Columnar distribution of activity dependent gabaergic depolarization in sensorimotor cortical neurons. Mol Brain 5:33
Whitsel, B L; Favorov, O V; Li, Y et al. (2010) Nociceptive afferent activity alters the SI RA neuron response to mechanical skin stimulation. Cereb Cortex 20:2900-15
Whitsel, Barry L; Favorov, Oleg V; Li, Yongbiao et al. (2009) Area 3a neuron response to skin nociceptor afferent drive. Cereb Cortex 19:349-66
Tommerdahl, M; Tannan, V; Cascio, C J et al. (2007) Vibrotactile adaptation fails to enhance spatial localization in adults with autism. Brain Res 1154:116-23
Lee, Jaekwang; Tommerdahl, M; Favorov, O V et al. (2005) Optically recorded response of the superficial dorsal horn: dissociation from neuronal activity, sensitivity to formalin-evoked skin nociceptor activation. J Neurophysiol 94:852-64
Tommerdahl, M; Hester, K D; Felix, E R et al. (2005) Human vibrotactile frequency discriminative capacity after adaptation to 25 Hz or 200 Hz stimulation. Brain Res 1057:1-9
Whitsel, B L; Kelly, E F; Quibrera, M et al. (2003) Time-dependence of SI RA neuron response to cutaneous flutter stimulation. Somatosens Mot Res 20:45-69
Tommerdahl, Mark; Favorov, Oleg; Whitsel, Barry L (2002) Optical imaging of intrinsic signals in somatosensory cortex. Behav Brain Res 135:83-91
Kohn, Adam; Whitsel, Barry L (2002) Sensory cortical dynamics. Behav Brain Res 135:119-26

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