The overall goal is to build micro-radiographic, small field-of-view imagers for detecting small vessels such as perforators and features such as stent wires which may be crucial to present and future cerebro- vascular interventions but which may not be normally visualized with present day systems. The new cameras will be used with catheter-based minimally invasive procedures to provide very high resolution (10 line pairs per mm) digital images of a region of interest (ROI) around the interventional site. The ROI micro-angiographic imagers will be based on a high resolution x-ray absorbing phosphor viewed through a slight fiberoptic taper by a large area silicon chip charge coupled device (CCD) light sensor. A series of increasingly automated insertion mechanisms and a computer workstation will be developed to allow the camera to be positioned and used with standard angiographic imaging equipment. Once built and characterized physically, the micro- angiographic ROI cameras will be evaluated in terms of the role such improved imaging capability might have during neuro-vascular interventions where devices such as stents and coils or materials such as glue are placed so as to treat vessel stenoses, aneurysms and arteriovenous malformations. Extensive phantom and animal studies to test the applicability to specific interventional tasks will occur simultaneously with gradual application to human procedures and evaluation by clinical interventionalists. The effect that the additional high resolution images from the new cameras may have on each decision made by the interventionalist during the course of the procedure will be analyzed to determine whether the procedure was altered and improved. Use for both single-plane and bi-plane micro- angiography and for providing data for 3D rendered vascular models will be investigated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS038746-01
Application #
2851918
Study Section
Special Emphasis Panel (ZRG1-DMG (01))
Program Officer
Jacobs, Tom P
Project Start
1999-02-08
Project End
2002-01-31
Budget Start
1999-02-08
Budget End
2000-01-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Rana, R; Singh, V; Jain, A et al. (2015) Anti-scatter grid artifact elimination for high resolution x-ray imaging CMOS detectors. Proc SPIE Int Soc Opt Eng 9412:
Jain, A; Takemoto, H; Silver, M D et al. (2015) Region-of-interest cone beam computed tomography (ROI CBCT) with a high resolution CMOS detector. Proc SPIE Int Soc Opt Eng 9412:
Russ, M; O'Hara, R; Setlur Nagesh, S V et al. (2015) Treatment Planning for Image-Guided Neuro-Vascular Interventions Using Patient-Specific 3D Printed Phantoms. Proc SPIE Int Soc Opt Eng 9417:
Wood, Rachel P; Khobragade, Parag; Ying, Leslie et al. (2015) Initial testing of a 3D printed perfusion phantom using digital subtraction angiography. Proc SPIE Int Soc Opt Eng 9417:
Vijayan, Sarath; Rana, Vijay K; Rudin, Stephen et al. (2015) Incorporating Corrections for the Head-Holder and Compensation Filter when Calculating Skin Dose during Fluoroscopically-Guided Interventions. Proc SPIE Int Soc Opt Eng 9412:94122I
Rana, Vijay K; Rudin, Stephen; Bednarek, Daniel R (2015) A Real-Time Skin Dose Tracking System for Biplane Neuro-Interventional Procedures. Proc SPIE Int Soc Opt Eng 9412:
Russ, M; Singh, V; Loughran, B et al. (2015) New Family of Generalized Metrics for Comparative Imaging System Evaluation. Proc SPIE Int Soc Opt Eng 9412:
Nagesh, S V Setlur; Khobragade, P; Ionita, C et al. (2015) A Combination of Spatial and Recursive Temporal Filtering for Noise Reduction when Using Region of Interest (ROI) Fluoroscopy for Patient Dose Reduction in Image Guided Vascular Interventions with Significant Anatomical Motion. Proc SPIE Int Soc Opt Eng 9412:
Khobragade, P; Jain, A; Setlur Nagesh, S V et al. (2015) Micro-Computed tomography (CT) based assessment of dental regenerative therapy in the canine mandible model. Proc SPIE Int Soc Opt Eng 9417:
Yoganand, Aradhana; Wood, Rachel P; Jimenez, Carlos et al. (2015) Angiographic analysis for phantom simulations of endovascular aneurysm treatments with a new fully retrievable asymmetric flow diverter. Proc SPIE Int Soc Opt Eng 9417:

Showing the most recent 10 out of 20 publications