Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS039098-05S1
Application #
6845644
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Mitler, Merrill
Project Start
2003-07-01
Project End
2008-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
5
Fiscal Year
2004
Total Cost
$10,893
Indirect Cost
Name
University of Miami School of Medicine
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
052780918
City
Miami
State
FL
Country
United States
Zip Code
33146
Liu, Yang; Grumbles, Robert M; Thomas, Christine K (2014) Electrical stimulation of transplanted motoneurons improves motor unit formation. J Neurophysiol 112:660-70
Grumbles, Robert M; Liu, Yang; Thomas, Christie M et al. (2013) Acute stimulation of transplanted neurons improves motoneuron survival, axon growth, and muscle reinnervation. J Neurotrauma 30:1062-9
Liu, Yang; Grumbles, Robert M; Thomas, Christine K (2013) Electrical stimulation of embryonic neurons for 1 hour improves axon regeneration and the number of reinnervated muscles that function. J Neuropathol Exp Neurol 72:697-707
Grumbles, Robert M; Almeida, Vania W; Casella, Gizelda T B et al. (2012) Motoneuron replacement for reinnervation of skeletal muscle in adult rats. J Neuropathol Exp Neurol 71:921-30
Casella, Gizelda T B; Almeida, Vania W; Grumbles, Robert M et al. (2010) Neurotrophic factors improve muscle reinnervation from embryonic neurons. Muscle Nerve 42:788-97
Grumbles, Robert M; Sesodia, Sanjay; Wood, Patrick M et al. (2009) Neurotrophic factors improve motoneuron survival and function of muscle reinnervated by embryonic neurons. J Neuropathol Exp Neurol 68:736-46
Grumbles, Robert M; Almeida, Vania W; Thomas, Christine K (2008) Embryonic neurons transplanted into the tibial nerve reinnervate muscle and reduce atrophy but NCAM expression persists. Neurol Res 30:183-9
Grumbles, Robert M; Casella, Gizelda T B; Rudinsky, Michelle J et al. (2007) Long-term delivery of FGF-6 changes the fiber type and fatigability of muscle reinnervated from embryonic neurons transplanted into adult rat peripheral nerve. J Neurosci Res 85:1933-42
Grumbles, R M; Casella, G T B; Rudinsky, M J et al. (2005) The immunophilin ligand FK506, but not the P38 kinase inhibitor SB203580, improves function of adult rat muscle reinnervated from transplants of embryonic neurons. Neuroscience 130:619-30
Baez, Juan Carlos; Gajavelli, Shyam; Thomas, Christine K et al. (2004) Embryonic cerebral cortex cells retain CNS phenotypes after transplantation into peripheral nerve. Exp Neurol 189:422-5

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