It has been recognized since the beginning of the AIDS epidemic that the brain may be an important reservoir for the human immunodeficiency virus (HIV). Drug development for treatment of HIV infection has progressed to the remarkable pace of two to three drugs being introduced in the clinic every year. However, we currently know very little about their ability to cross the blood brain and brain-cerebrospinal fluid barriers and almost nothing about their ability to enter susceptible cells in the brain, form active metabolites within these cells, or their ability to incorporate into HIV DNA and inhibit its replication. In this proposal we will examine each of six clinically used antiretroviral nucleoside analogs targeted against the reverse transcriptase enzyme and determine their ability to enter human glial cells, to form active metabolites, and to control HIV infection in these cells.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS039184-03
Application #
6394243
Study Section
Special Emphasis Panel (ZNS1-SRB-P (01))
Program Officer
Pollock, Jonathan D
Project Start
1999-08-01
Project End
2002-08-31
Budget Start
2001-08-01
Budget End
2002-08-31
Support Year
3
Fiscal Year
2001
Total Cost
$213,862
Indirect Cost
Name
University of Kentucky
Department
Neurology
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
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