The experiments proposed here will examine properties of the dynamic stability of the movements produced by the nervous system. These experiments will focus on the movements produced by neural systems located within the spinal cord, characterizing first how the movements respond to dynamic perturbations and second how these neural systems are organized for the production of stable movements. The basic results from these experiments will therefore provide important information about the role of the spinal cord in the production of movement. By describing the limits and extent of the control of stability by spinal motor systems, we will gain a better understanding of how this control can be augmented and exploited to produce purposeful movements when the spinal cord is isolated. These experiments are designed primarily to provide such information. At the same time, these experiments are designed to examine an exciting and potentially powerful hypothesis of the production of movement by the nervous system. If these experiments find that spinal motor systems produce stable movements through the implementation of a version of sliding control, this motor systems produce stable movements through the implementation of a version of sliding control, this will be of fundamental importance in our understanding of the neural control of movement. However, we stress that the results from these experiments have been designed to provide important information on their own, regardless of whether or not they are consistent with this novel hypothesis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS039865-04
Application #
6637694
Study Section
Special Emphasis Panel (ZRG1-IFCN-5 (01))
Program Officer
Kleitman, Naomi
Project Start
2000-03-01
Project End
2005-02-28
Budget Start
2003-03-01
Budget End
2004-02-29
Support Year
4
Fiscal Year
2003
Total Cost
$280,456
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Other Basic Sciences
Type
Other Domestic Higher Education
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Tresch, Matthew C; Cheung, Vincent C K; d'Avella, Andrea (2006) Matrix factorization algorithms for the identification of muscle synergies: evaluation on simulated and experimental data sets. J Neurophysiol 95:2199-212
Cheung, Vincent C K; d'Avella, Andrea; Tresch, Matthew C et al. (2005) Central and sensory contributions to the activation and organization of muscle synergies during natural motor behaviors. J Neurosci 25:6419-34
Richardson, Andrew G; Slotine, Jean-Jacques E; Bizzi, Emilio et al. (2005) Intrinsic musculoskeletal properties stabilize wiping movements in the spinalized frog. J Neurosci 25:3181-91
Perrier, Jean-Francois; Tresch, Matthew C (2005) Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog. J Physiol 562:507-20
Tresch, Matthew C; Saltiel, Philippe; d'Avella, Andrea et al. (2002) Coordination and localization in spinal motor systems. Brain Res Brain Res Rev 40:66-79