Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS042025-02
Application #
6681867
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Nunn, Michael
Project Start
2002-12-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$211,613
Indirect Cost
Name
University of Maryland College Park
Department
Biology
Type
Schools of Earth Sciences/Natur
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
Chang, Kai-Ti; Anishkin, Andriy; Patwardhan, Gauri A et al. (2015) Ceramide channels: destabilization by Bcl-xL and role in apoptosis. Biochim Biophys Acta 1848:2374-84
Colombini, Marco (2012) VDAC structure, selectivity, and dynamics. Biochim Biophys Acta 1818:1457-65
Colombini, Marco; Mannella, Carmen A (2012) VDAC, the early days. Biochim Biophys Acta 1818:1438-43
Samanta, Soumya; Stiban, Johnny; Maugel, Timothy K et al. (2011) Visualization of ceramide channels by transmission electron microscopy. Biochim Biophys Acta 1808:1196-201
Siskind, Leah J; Feinstein, Laurence; Yu, Tingxi et al. (2008) Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels. J Biol Chem 283:6622-30
Stiban, Johnny; Caputo, Laura; Colombini, Marco (2008) Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins. J Lipid Res 49:625-34
Tan, Wenzhi; Colombini, Marco (2007) VDAC closure increases calcium ion flux. Biochim Biophys Acta 1768:2510-5
Colombini, Marco (2007) Measurement of VDAC permeability in intact mitochondria and in reconstituted systems. Methods Cell Biol 80:241-60
Anishkin, A; Sukharev, S; Colombini, M (2006) Searching for the molecular arrangement of transmembrane ceramide channels. Biophys J 90:2414-26
Siskind, Leah J; Kolesnick, Richard N; Colombini, Marco (2006) Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations. Mitochondrion 6:118-25

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