This proposal introduces a novel, non-invasive and painless method for the evaluation of skeletal muscle, using a recently developed technique called electrical impedance myography (EIM). The ultimate goal of this research is to refine ElM as a clinical test that can assist in the diagnosis and treatment of neuromuscular disease and in evaluation of muscle change due to disuse. In addition to complementing and potentially replacing the painful test of needle electromyography, ElM will have unique application in the evaluation of muscle weakness in clinical trials research, rehabilitation, and space flight.
Our first aim i s to establish normal values and confirm the reproducibility of this technique by performing studies on healthy subjects of varying age and fluid status. Second, patients with different disease and disuse states will be evaluated to determine ElM patterns associated with myopathy vs. neurogenic disease and compare the specificity and sensitivity of these patterns to well-established diagnostic methods. Finally, ElM's use as a tool in evaluating neuromuscular disease progression/remission will be assessed and refined. As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS042037-03
Application #
6893286
Study Section
Special Emphasis Panel (ZRG1-SSS-M (01))
Program Officer
Porter, John D
Project Start
2003-05-01
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
3
Fiscal Year
2005
Total Cost
$392,252
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
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Shiffman, C A; Rutkove, S B (2013) Circuit modeling of the electrical impedance: I. Neuromuscular disease. Physiol Meas 34:203-21
Shiffman, C A; Rutkove, S B (2013) Circuit modeling of the electrical impedance: II. Normal subjects and system reproducibility. Physiol Meas 34:223-35
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Rutkove, Seward (2009) Electrical impedance myography as a biomarker for ALS. Lancet Neurol 8:226; author reply 227
Tarulli, Andrew W; Duggal, Naven; Esper, Gregory J et al. (2009) Electrical impedance myography in the assessment of disuse atrophy. Arch Phys Med Rehabil 90:1806-10

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