Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS042960-05
Application #
7071119
Study Section
Special Emphasis Panel (ZRG1-CNBT (01))
Program Officer
Nunn, Michael
Project Start
2001-12-15
Project End
2010-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
5
Fiscal Year
2006
Total Cost
$332,288
Indirect Cost

  Institution

Name
Tufts University
Department
Pathology
Type
Schools of Medicine
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Salvador, Ryan; Aridgides, Daniel; PereiraPerrin, Mercio (2014) Parasite-derived neurotrophic factor/trans-sialidase of Trypanosoma cruzi links neurotrophic signaling to cardiac innate immune response. Infect Immun 82:3687-96
Aridgides, Daniel; Salvador, Ryan; PereiraPerrin, Mercio (2013) Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA. PLoS One 8:e57450
Aridgides, Daniel; Salvador, Ryan; PereiraPerrin, Mercio (2013) Trypanosoma cruzi highjacks TrkC to enter cardiomyocytes and cardiac fibroblasts while exploiting TrkA for cardioprotection against oxidative stress. Cell Microbiol 15:1357-66
Chuenkova, Marina V; Pereiraperrin, Mercio (2010) Trypanosoma cruzi-Derived Neurotrophic Factor: Role in Neural Repair and Neuroprotection. J Neuroparasitology 1:55-60
Lu, B; Luquetti, A O; Rassi, A et al. (2010) Autoantibodies to neurotrophic receptors TrkA, TrkB and TrkC in patients with acute Chagas' disease. Scand J Immunol 71:220-5
Chuenkova, Marina V; PereiraPerrin, Mercio (2009) Trypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategy. Sci Signal 2:ra74
Weinkauf, Craig; Pereiraperrin, Mercio (2009) Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC. Infect Immun 77:1368-75
Lu, B; Petrola, Z; Luquetti, A O et al. (2008) Auto-antibodies to receptor tyrosine kinases TrkA, TrkB and TrkC in patients with chronic Chagas'disease. Scand J Immunol 67:603-9
Akpan, Nsikan; Caradonna, Kacey; Chuenkova, Marina V et al. (2008) Chagas'disease parasite-derived neurotrophic factor activates cholinergic gene expression in neuronal PC12 cells. Brain Res 1217:195-202
Lu, Bo; Alroy, Joseph; Luquetti, Alejandro O et al. (2008) Human autoantibodies specific for neurotrophin receptors TrkA, TrkB, and TrkC protect against lethal Trypanosoma cruzi infection in mice. Am J Pathol 173:1406-14

Showing the most recent 10 out of 15 publications