Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS043244-02
Application #
6685203
Study Section
Special Emphasis Panel (ZRG1-MDCN-4 (01))
Program Officer
Stewart, Randall R
Project Start
2002-12-01
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$348,413
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Other Basic Sciences
Type
Other Domestic Higher Education
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Melom, Jan E; Littleton, J Troy (2013) Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility. J Neurosci 33:1169-78
Weiss, Kurt R; Kimura, Yoko; Lee, Wyan-Ching Mimi et al. (2012) Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model. Genetics 190:581-600
Guan, Zhuo; Buhl, Lauren K; Quinn, William G et al. (2011) Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. Learn Mem 18:191-206
Schulte, Joost; Littleton, J Troy (2011) The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathology. Curr Trends Neurol 5:65-78
Rodal, Avital A; Blunk, Aline D; Akbergenova, Yulia et al. (2011) A presynaptic endosomal trafficking pathway controls synaptic growth signaling. J Cell Biol 193:201-17
Schulte, Joost; Sepp, Katharine J; Wu, Chaohong et al. (2011) High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model. PLoS One 6:e23841
Wu, Chaohong; Schulte, Joost; Sepp, Katharine J et al. (2010) Automatic robust neurite detection and morphological analysis of neuronal cell cultures in high-content screening. Neuroinformatics 8:83-100
Schulte, Joost; Sepp, Katharine J; Jorquera, Ramon A et al. (2010) DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. J Neurosci 30:5189-203
Zhang, Sheng; Feany, Mel B; Saraswati, Sudipta et al. (2009) Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. Dis Model Mech 2:247-66
Barber, Cynthia F; Jorquera, Ramon A; Melom, Jan E et al. (2009) Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. J Cell Biol 187:295-310

Showing the most recent 10 out of 14 publications