Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS043277-01A1S1
Application #
6684371
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Behar, Toby
Project Start
2002-09-30
Project End
2007-07-31
Budget Start
2002-09-30
Budget End
2003-07-31
Support Year
1
Fiscal Year
2003
Total Cost
$116,687
Indirect Cost
Name
University of Pittsburgh
Department
Biology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Justice, Jason A; Manjooran, Daniel T; Yeh, Chung-Yang et al. (2018) Molecular Neuroprotection Induced by Zinc-Dependent Expression of Hepatitis C-Derived Protein NS5A Targeting Kv2.1 Potassium Channels. J Pharmacol Exp Ther 367:348-355
Justice, Jason A; Schulien, Anthony J; He, Kai et al. (2017) Disruption of KV2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents. Neuroscience 354:158-167
Yeh, Chung-Yang; Bulas, Ashlyn M; Moutal, Aubin et al. (2017) Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke. J Neurosci 37:5648-5658
Schulien, Anthony J; Justice, Jason A; Di Maio, Roberto et al. (2016) Zn(2+) -induced Ca(2+) release via ryanodine receptors triggers calcineurin-dependent redistribution of cortical neuronal Kv2.1 K(+) channels. J Physiol 594:2647-59
Li, Dong; Yuan, Hongjie; Ortiz-Gonzalez, Xilma R et al. (2016) GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. Am J Hum Genet 99:802-816
Clemens, Katerina; Yeh, Chung-Yang; Aizenman, Elias (2015) Critical role of Casein kinase 2 in hepatitis C NS5A-mediated inhibition of Kv2.1 K(+) channel function. Neurosci Lett 609:48-52
Aizenman, Elias; Mastroberardino, Pier G (2015) Metals and neurodegeneration. Neurobiol Dis 81:1-3
He, Kai; McCord, Meghan C; Hartnett, Karen A et al. (2015) Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels. PLoS One 10:e0129498
Hershfinkel, Michal; Ford, Dianne; Kelleher, Shannon et al. (2015) Seashells by the zinc shore: a meeting report of the International Society for Zinc Biology, Asilomar, CA 2014. Metallomics 7:1299-304
Gilad, David; Shorer, Sharon; Ketzef, Maya et al. (2015) Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures. Neurobiol Dis 81:4-13

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