We propose a post-doctoral training program in pediatric infectious diseases and immunity (PIDI-TP) based in the Pediatric Infectious Diseases Division of Washington University (WU)/St. Louis Children's Hospital. The long-term objective is to train academic physician-scientists to carry out research in pediatric infectious diseases including host response to infections. WU Medical Center offers an outstanding training environment for physician-scientists with nationally recognized hospitals conjoined with one of the nation's premier biomedical research facilities. Many Washington University faculty members are leading investigators in infectious diseases and human immunology. PIDI-TP will also take advantage of the WU Genome Institute, one of the world's most advanced genome sequencing centers that has played a leading role in the Human Microbiome Project. PIDI-TP mentors, drawn from the WU Departments of Pediatrics, Medicine, Pathology & Immunology, and Molecular Microbiology are highly successful investigators with independent research programs and experience in mentoring physician-scientists. The PIDI-TP Program Director will be Gregory Storch, Professor of Pediatrics and Director of the Division of Pediatric Infectious Diseases. The co-Program Director will be Thad Stappenbeck, Associate Professor of Pathology & Immunology. An Advisory Committee consisting of three senior WU faculty members and one distinguished outside member will advise the PD and co-PD. An Executive Committee will oversee recruitment and selection of trainees, monitor the performance and career development of trainees, and evaluate program operations and outcomes. Trainees will also report to Scholarship Oversight Committees, whose findings will be reviewed by the PD, co-PD, and Executive Committee. Support is requested for two trainees per year, to be recruited from pediatric fellowship programs in Infectious Diseases, Rheumatology, Neonatology, Allergy/Pulmonary/Immunology, Nephrology, and Critical Care, and from residents at St. Louis Children's Hospital, especially those with MD and PhD degrees. This pool of applicants is sufficient to fill the positions requested. Trainees will be assigned to one of three tracks: Pathogens, Host, and Genomics/Microbiome/Pathogen Discovery. Each PIDI-TP trainee will have a major research experience under the supervision of a program mentor. A Core Curriculum will provide training in study design, biostatistics, research ethics, human subjects, animal subjects, scientific writing, preparation of grants, and genomics, and will be supplemented by an individualized curriculum, specific for the trainee's chosen track. Trainees will also receive assistance in career planning and in preparation for subspecialty Board examinations. Career development will be monitored by research mentors, the PD and co-PD, the Executive Committee and the SOCs. Program evaluation will include short-term and long-term metrics plus input from current and past trainees. Efforts will be made to enhance diversity of trainees and mentors.

Public Health Relevance

The proposed postdoctoral training program in pediatric infectious diseases and immunology will train academic physician-scientists to perform research in infectious diseases and immunity of children. Infectious diseases still account for extensive morbidity and mortality throughout the world, and trained researchers are needed who can apply powerful new scientific methods to bring these diseases under control. One of the areas of emphasis of this proposal will be the use of powerful new methods to study microbial and human genomics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI106688-02
Application #
8901922
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Coomes, Stephanie
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
2
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Rosen, David A; Twentyman, Joy; Hunstad, David A (2018) High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung. Infect Immun 86:
Zhong, Huaqing; Hu, Xinran; Janowski, Andrew B et al. (2017) Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection. Sci Rep 7:17775
Hall, Chase; Nici, Linda; Sood, Shweta et al. (2017) Nonpharmacologic Therapy for Severe Persistent Asthma. J Allergy Clin Immunol Pract 5:928-935
Janowski, Andrew B; Bauer, Irma K; Holtz, Lori R et al. (2017) Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture. J Virol :
Janowski, Andrew B; Krishnamurthy, Siddharth R; Lim, Efrem S et al. (2017) Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology 504:36-44
Trivedi, Abhaya; Hall, Chase; Hoffman, Eric A et al. (2017) Using imaging as a biomarker for asthma. J Allergy Clin Immunol 139:1-10
Rosen, David A; Hilliard, Julia K; Tiemann, Kristin M et al. (2016) Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia. J Infect Dis 213:649-58
Reich, P J; Boyle, M G; Hogan, P G et al. (2016) Emergence of community-associated methicillin-resistant Staphylococcus aureus strains in the neonatal intensive care unit: an infection prevention and patient safety challenge. Clin Microbiol Infect 22:645.e1-8
Krishnamurthy, Siddharth R; Janowski, Andrew B; Zhao, Guoyan et al. (2016) Hyperexpansion of RNA Bacteriophage Diversity. PLoS Biol 14:e1002409
Janowski, Andrew B; Michaels, Marian G; Martin, Judith M et al. (2016) Piperacillin-Tazobactam Usage at a Tertiary Pediatric Hospital: An Antimicrobial Stewardship Review. J Pediatric Infect Dis Soc 5:342-5