Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS043300-02
Application #
6688946
Study Section
Special Emphasis Panel (ZRG1-BDCN-1 (01))
Program Officer
Jacobs, Tom P
Project Start
2002-12-15
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$267,330
Indirect Cost
Name
Veterans Medical Research Fdn/San Diego
Department
Type
DUNS #
933863508
City
San Diego
State
CA
Country
United States
Zip Code
92161
Shih, Andy Y; Nishimura, Nozomi; Nguyen, John et al. (2013) Optically induced occlusion of single blood vessels in rodent neocortex. Cold Spring Harb Protoc 2013:1153-60
Chen, Bo; Van Winkle, Jessica A; Lyden, Patrick D et al. (2013) PHLPP1 gene deletion protects the brain from ischemic injury. J Cereb Blood Flow Metab 33:196-204
Chen, Bo; Cheng, Qun; Yang, Kai et al. (2010) Thrombin mediates severe neurovascular injury during ischemia. Stroke 41:2348-52
Tsai, Philbert S; Kaufhold, John P; Blinder, Pablo et al. (2009) Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci 29:14553-70
Chen, Bo; Friedman, Beth; Cheng, Qun et al. (2009) Severe blood-brain barrier disruption and surrounding tissue injury. Stroke 40:e666-74
Friedman, Beth; Schachtrup, Christian; Tsai, Philbert S et al. (2009) Acute vascular disruption and aquaporin 4 loss after stroke. Stroke 40:2182-90
Yu, Sung Wook; Friedman, Beth; Cheng, Qun et al. (2007) Stroke-evoked angiogenesis results in a transient population of microvessels. J Cereb Blood Flow Metab 27:755-63
Nishimura, Nozomi; Schaffer, Chris B; Friedman, Beth et al. (2007) Penetrating arterioles are a bottleneck in the perfusion of neocortex. Proc Natl Acad Sci U S A 104:365-70
Nishimura, Nozomi; Schaffer, Chris B; Friedman, Beth et al. (2006) Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat Methods 3:99-108
Schaffer, Chris B; Friedman, Beth; Nishimura, Nozomi et al. (2006) Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS Biol 4:e22

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