Narcolepsy is estimated to have a genetic link: 8 percent to 12 percent of individuals with narcolepsy have a close relative with the disease. The importance of this link, however, is not well known; between the full-fledge manifestation of the syndrome and its absence, it may exist sub-syndromes that can be associated with genetic markers of narcolepsy. The proposed research focuses on the identification of specific symptomatology patterns that will constitute the narcolepsy spectrum in narcoleptic patients and their family. All narcoleptic subjects (about 200) coming from the Narcolepsy Center of the Stanford University and their first-degree family (parents (mother and father if still alive), sibling and children 12 years or older) will be interviewed by telephone using the Sleep-EVAL system. A control group for environmental factors composed of spouses or roommates of narcoleptic subjects will also be interviewed. At the first step, the narcoleptic subjects will be contacted by telephone. The interviewer will explain the study and will ask them if they want to participate in the survey. Subjects who want further information will be send an official letter if they willing so, or they could also call one of the researcher involved in the project. Once the consent obtained, the interviewer will ask the narcoleptic subject to provide the names and telephones number of his/her father and mother, brother(s) and sister(s) and children. A blood sample (3-5 ml) will be asked also to all participants. This will allow us to link some genetic markers of narcolepsy to specific symptoms even in subjects without the full-fledge manifestation of the disease.
| Ohayon, Maurice M; Black, Jed; Lai, Chinglin et al. (2014) Increased mortality in narcolepsy. Sleep 37:439-44 |
| Ohayon, Maurice M; Reynolds 3rd, Charles F; Dauvilliers, Yves (2013) Excessive sleep duration and quality of life. Ann Neurol 73:785-94 |
| Ohayon, Maurice M (2013) Narcolepsy is complicated by high medical and psychiatric comorbidities: a comparison with the general population. Sleep Med 14:488-92 |
| Ohayon, M M; Mahowald, M W; Dauvilliers, Y et al. (2012) Prevalence and comorbidity of nocturnal wandering in the U.S. adult general population. Neurology 78:1583-9 |
| Ohayon, Maurice M; O'Hara, Ruth; Vitiello, Michael V (2012) Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev 16:283-95 |
| Ohayon, Maurice M; Riemann, Dieter; Morin, Charles et al. (2012) Hierarchy of insomnia criteria based on daytime consequences. Sleep Med 13:52-7 |
| Ohayon, Maurice M; Dauvilliers, Yves; Reynolds 3rd, Charles F (2012) Operational definitions and algorithms for excessive sleepiness in the general population: implications for DSM-5 nosology. Arch Gen Psychiatry 69:71-9 |
| Kornum, Birgitte R; Kawashima, Minae; Faraco, Juliette et al. (2011) Common variants in P2RY11 are associated with narcolepsy. Nat Genet 43:66-71 |
| Ohayon, Maurice M; Krystal, Andrew; Roehrs, Timothy A et al. (2010) Using difficulty resuming sleep to define nocturnal awakenings. Sleep Med 11:236-41 |
| Ohayon, Maurice M (2010) Nocturnal awakenings and difficulty resuming sleep: their burden in the European general population. J Psychosom Res 69:565-71 |
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