Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS045041-02
Application #
6689011
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (01))
Program Officer
Owens, David F
Project Start
2002-12-15
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$305,663
Indirect Cost
Name
Henry Ford Health System
Department
Neurology
Type
Schools of Medicine
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202
Shen, L H; Li, Y; Chopp, M (2010) Astrocytic endogenous glial cell derived neurotrophic factor production is enhanced by bone marrow stromal cell transplantation in the ischemic boundary zone after stroke in adult rats. Glia 58:1074-81
Zhang, Jing; Chen, Jieli; Li, Yi et al. (2008) Niaspan treatment improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. Neurobiol Dis 32:273-80
Zhang, Jing; Li, Yi; Zheng, Xuguang et al. (2008) Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury. J Neurosci Res 86:1501-10
Chopp, Michael; Li, Yi; Zhang, Jing (2008) Plasticity and remodeling of brain. J Neurol Sci 265:97-101
Shen, Li Hong; Li, Yi; Gao, Qi et al. (2008) Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain. Glia 56:1747-54
Gao, Q; Li, Y; Shen, L et al. (2008) Bone marrow stromal cells reduce ischemia-induced astrocytic activation in vitro. Neuroscience 152:646-55
Liu, Zhongwu; Li, Yi; Qu, Runjiang et al. (2007) Axonal sprouting into the denervated spinal cord and synaptic and postsynaptic protein expression in the spinal cord after transplantation of bone marrow stromal cell in stroke rats. Brain Res 1149:172-80
Shen, Li Hong; Li, Yi; Chen, Jieli et al. (2007) Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab 27:6-13
Shen, Li Hong; Li, Yi; Chen, Jieli et al. (2007) One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke. Stroke 38:2150-6
Qu, Runjiang; Li, Yi; Gao, Qi et al. (2007) Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts. Neuropathology 27:355-63

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